A new crown ether as vesicular carrier for 5-fluoruracil: Synthesis, characterization and drug delivery evaluation

被引：45

作者：

Muzzalupo, Rita ^{[1
]}

Nicoletta, Fiore Pasquale ^{[1
]}

Trombino, Sonia ^{[1
]}

Cassano, Roberta ^{[1
]}

Iemma, Francesca ^{[1
]}

Picci, Nevio ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Sci Farmaceut, I-87030 Arcavacata Di Rende, Italy

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2007年 / 58卷 / 02期

关键词：

niosomes; crown ether; drug delivery; 5-fluorouracil; in vitro delivery;

D O I：

10.1016/j.colsurfb.2007.03.010

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Niosomes have shown promise as cheap and chemically stable drug delivery systems. In this paper a novel crown ether amphiphile, 1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (Bola A-16), has been synthesized with the aim of developing a long time stable controlled release system. Niosomes have been prepared with different molar ratios of amphiphile and cholesterol and their morphological properties have been determined by quasi-elastic light scattering and transmission electron microscopy. The composition of niosomes affects the entrapment efficiency and the release rate of 5-fluorouracil, a well-known antineoplastic molecule. In addition, other two known azacrown ether amphiphiles (4,710.13-pentaoxa-16-aza-cyclooctadecane)-hexadecanedioc acid diamide (Bola D-16) and alpha,omega-(4,7,10,13-pentaoxa-16-aza-cyclooctadecane)hexadecane (Bola C-16), have been synthesized and the obtained vesicles have been characterized for comparison. Furthermore, the release profile of 5-fluorouracil in vitro, from these niosomes, has been studied over a period of 6 h in order to simulate a hematic adsorption. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：197 / 202

页数：6

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