B Cell Function in the Tumor Microenvironment

被引：189

作者：

Downs-Canner, Stephanie M. ^{[1
,2
]}

Meier, Jeremy ^{[3
]}

Vincent, Benjamin G. ^{[3
,4
,5
]}

Serody, Jonathan S. ^{[3
,5
]}

机构：

[1] Univ N Carolina, Dept Surg, Sch Med, Chapel Hill, NC 27515 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27515 USA

[3] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA

[4] Univ N Carolina, Bioinformat & Computat Biol Program, Sch Med, Chapel Hill, NC 27515 USA

[5] Univ N Carolina, Dept Microbiol & Immunol, Sch Med, Chapel Hill, NC 27515 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2022年 / 40卷

基金：

美国国家卫生研究院;

关键词：

tumor microenvironment; B cell; Breg; antibody; immunogenomics; tertiary lymphoid structure; TERTIARY LYMPHOID STRUCTURES; REGULATORY T-CELLS; IMMUNE CHECKPOINT BLOCKADE; BREAST-CANCER; PROGNOSTIC VALUE; ADVANCED MELANOMA; GERMINAL-CENTERS; CLINICAL BENEFIT; GENE SIGNATURES; PLASMA-CELLS;

D O I：

10.1146/annurev-immunol-101220-015603

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and innate and adaptive immune cells. Over the last decade, it has become increasingly clear that the immune cells in the TME play a critical role in controlling or promoting tumor growth. The function of T lymphocytes in this process has been well characterized. On the other hand, the function of B lymphocytes is less clear, although recent data from our group and others have strongly indicated a critical role for B cells in antitumor immunity. There are, however, a multitude of populations of B cells found within the TME, ranging from naive B cells all the way to terminally differentiated plasma cells and memory B cells. Here, we characterize the role of B cells in the TME in both animal models and patients, with an emphasis on dissecting how B cell heterogeneity contributes to the immune response to cancer.

引用

页码：169 / 193

页数：25

共 167 条

[1] Dual roles for immune metagenes in breast cancer prognosis and therapy prediction [J].

Alistar, Angela ;

Chou, Jeff W. ;

Nagalla, Srikanth ;

Black, Michael A. ;

D'Agostino, Ralph, Jr. ;

Miller, Lance D. .

GENOME MEDICINE, 2014, 6

[2] Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function [J].

Allen, Christopher D. C. ;

Cyster, Jason G. .

SEMINARS IN IMMUNOLOGY, 2008, 20 (01) :14-25

[3] The establishment of resident memory B cells in the lung requires local antigen encounter [J].

Allie, S. Rameeza ;

Bradley, John E. ;

Mudunuru, Uma ;

Schultz, Michael D. ;

Graf, Beth A. ;

Lund, Frances E. ;

Randall, Troy D. .

NATURE IMMUNOLOGY, 2019, 20 (01) :97-+

[4] B-cell-derived lymphotoxin promotes castration-resistant prostate cancer [J].

Ammirante, Massimo ;

Luo, Jun-Li ;

Grivennikov, Sergei ;

Nedospasov, Sergei ;

Karin, Michael .

NATURE, 2010, 464 (7286) :302-U187

[5] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis [J].

Andreu, Pauline ;

Johansson, Magnus ;

Affara, Nesrine I. ;

Pucci, Ferdinando ;

Tan, Tingting ;

Junankar, Simon ;

Korets, Lidiya ;

Lam, Julia ;

Tawfik, David ;

DeNardo, David G. ;

Naldini, Luigi ;

de Visser, Karin E. ;

De Palma, Michele ;

Coussens, Lisa M. .

CANCER CELL, 2010, 17 (02) :121-134

[6] CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity [J].

Ansel, KM ;

Harris, RBS ;

Cyster, JG .

IMMUNITY, 2002, 16 (01) :67-76

[7] Molecular Anatomy of Breast Cancer Stroma and Its Prognostic Value in Estrogen Receptor-Positive and -Negative Cancers [J].

Bianchini, Giampaolo ;

Qi, Yuan ;

Alvarez, Ricardo H. ;

Iwamoto, Takayuki ;

Coutant, Charles ;

Ibrahim, Nuhad K. ;

Valero, Vicente ;

Cristofanilli, Massimo ;

Green, Marjorie C. ;

Radvanyi, Laszlo ;

Hatzis, Christos ;

Hortobagyi, Gabriel N. ;

Andre, Fabrice ;

Gianni, Luca ;

Symmans, W. Fraser ;

Pusztai, Lajos .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (28) :4316-4323

[8] Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer [J].

Bindea, Gabriela ;

Mlecnik, Bernhard ;

Tosolini, Marie ;

Kirilovsky, Amos ;

Waldner, Maximilian ;

Obenauf, Anna C. ;

Angell, Helen ;

Fredriksen, Tessa ;

Lafontaine, Lucie ;

Berger, Anne ;

Bruneval, Patrick ;

Fridman, Wolf Herman ;

Becker, Christoph ;

Pages, Franck ;

Speicher, Michael R. ;

Trajanoski, Zlatko ;

Galon, Jerome .

IMMUNITY, 2013, 39 (04) :782-795

[9] IgA transcytosis and antigen recognition govern ovarian cancer immunity [J].

Biswas, Subir ;

Mandal, Gunjan ;

Payne, Kyle K. ;

Anadon, Carmen M. ;

Gatenbee, Chandler D. ;

Chaurio, Ricardo A. ;

Costich, Tara Lee ;

Moran, Carlos ;

Harro, Carly M. ;

Rigolizzo, Kristen E. ;

Mine, Jessica A. ;

Trillo-Tinoco, Jimena ;

Sasamoto, Naoko ;

Terry, Kathryn L. ;

Marchion, Douglas ;

Buras, Andrea ;

Wenham, Robert M. ;

Yu, Xiaoqing ;

Townsend, Mary K. ;

Tworoger, Shelley S. ;

Rodriguez, Paulo C. ;

Anderson, Alexander R. ;

Conejo-Garcia, Jose R. .

NATURE, 2021, 591 (7850) :464-+

[10] Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice [J].

Blair, Paul A. ;

Chavez-Rueda, Karina A. ;

Evans, Jamie G. ;

Shlomchik, Mark J. ;

Eddaoudi, Ayad ;

Isenberg, David A. ;

Ehrenstein, Michael R. ;

Mauri, Claudia .

JOURNAL OF IMMUNOLOGY, 2009, 182 (06) :3492-3502

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