Vectors for gene therapy of skin diseases

被引：2

作者：

Pfuetzner, Wolfgang ^{[1
]}

机构：

[1] Univ Marburg, Klin Dermatol & Allergol, D-35037 Marburg, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2010年 / 8卷 / 08期

关键词：

gene therapy; plasmid; retrovirus; adeno-associated virus; adenovirus; genodermatosis; JUNCTIONAL EPIDERMOLYSIS-BULLOSA; IN-VIVO; PLASMID DNA; INTRATUMORAL INJECTION; TRANSGENE EXPRESSION; METASTATIC MELANOMA; HUMAN KERATINOCYTES; ADENOVIRAL VECTORS; HAIR-FOLLICLES; PHASE-I;

D O I：

10.1111/j.1610-0387.2010.07435.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The success of gene therapy mainly depends on the gene vector (GV) responsible for the efficient transport of genetic information. The qualities of a GV have a profound influence on the method of application, the efficiency of gene transfer in the target tissue, the amount and persistence of gene expression and the potential side effects and safety risks. Clinical gene therapy studies over the past 20 years have contributed to the development and testing of different GV systems, some of which also show great potential for the treatment of skin diseases. In this review the structures, methods of application, characteristics, clinical uses and possibilities for optimization of these GV will be discussed with regard to their cutaneous applications.

引用

页码：582 / 591

页数：10

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