Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

被引：10
|
作者：
Beguelin, C. [1 ]
Vazquez, M. [1 ]
Bertschi, M. [2 ,3 ]
Yerly, S. [4 ]
de Jong, D. [2 ,3 ]
Gutbrod, K. [2 ,3 ]
Rauch, A. [1 ]
Cusini, A. [1 ,5 ]
机构：
[1] Univ Bern, Univ Hosp Bern, Inselspital, Dept Infect Dis, CH-3006 Bern, Switzerland
[2] Univ Hosp Bern, Dept Neurol, Bern, Switzerland
[3] Univ Bern, CH-3006 Bern, Switzerland
[4] Univ Hosp Geneva, Lab Virol, Geneva, Switzerland
[5] Cantonal Hosp, Infect Dis Unit, Chur, Switzerland
来源：
OPEN FORUM INFECTIOUS DISEASES | 2016年 / 3卷 / 01期
关键词：
central nervous system; HIV; K65R; viral escape; multidrug-resistant; ANTIRETROVIRAL THERAPY; CEREBROSPINAL-FLUID; TISSUES; TROPISM; BRAIN;
D O I：
10.1093/ofid/ofv210
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.
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页数：4
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