Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex

被引：0
|
作者：
Shouksmith, Andrew E. [1 ]
Evans, Laura E. [2 ]
Griffin, Roger J. [1 ,2 ]
Golding, Bernard T. [1 ,2 ]
Newell, Herbie [1 ,2 ]
Miller, Duncan C. [1 ]
Noble, Martin E. M. [1 ,2 ]
Endicott, Jane A. [1 ,2 ]
Tweddle, Deborah [2 ]
机构：
[1] Newcastle Univ, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Newcastle Canc Ctr, Dept Canc Res, Newcastle Upon Tyne, Tyne & Wear, England
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 247卷
关键词：
CANCER; P27;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
318-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
    Shirish Shukla
    Weijiang Ying
    Felicia Gray
    Yiwu Yao
    Miranda L. Simes
    Qingjie Zhao
    Hongzhi Miao
    Hyo Je Cho
    Paula González-Alonso
    Alyssa Winkler
    George Lund
    Trupta Purohit
    EunGi Kim
    Xiaotian Zhang
    Joshua M. Ray
    Shihan He
    Caroline Nikolaidis
    Juliano Ndoj
    Jingya Wang
    Łukasz Jaremko
    Mariusz Jaremko
    Russell J. H. Ryan
    Monica L. Guzman
    Jolanta Grembecka
    Tomasz Cierpicki
    Nature Chemical Biology, 2021, 17 : 784 - 793
  • [32] Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
    Shukla, Shirish
    Ying, Weijiang
    Gray, Felicia
    Yao, Yiwu
    Simes, Miranda L.
    Zhao, Qingjie
    Miao, Hongzhi
    Cho, Hyo Je
    Gonzalez-Alonso, Paula
    Winkler, Alyssa
    Lund, George
    Purohit, Trupta
    Kim, EunGi
    Zhang, Xiaotian
    Ray, Joshua M.
    He, Shihan
    Nikolaidis, Caroline
    Ndoj, Juliano
    Wang, Jingya
    Jaremko, Lukasz
    Jaremko, Mariusz
    Ryan, Russell J. H.
    Guzman, Monica L.
    Grembecka, Jolanta
    Cierpicki, Tomasz
    NATURE CHEMICAL BIOLOGY, 2021, 17 (07) : 784 - 793
  • [33] Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity
    Rothenaigner, Ina
    Brenke, Jara Kerstin
    Schorpp, Kenji
    Hadian, Kamyar
    CURRENT PROTOCOLS, 2022, 2 (04):
  • [34] A potential SCFSKP2 E3 ligase modulator for p27KIP1 stabilization and apoptosis in multiple myeloma MM-1s cells.
    Xu, WM
    De Parserval, L
    Bennett, B
    Stein, B
    BLOOD, 2003, 102 (11) : 596A - 596A
  • [35] Synthesis and Activity of Putative Small-Molecule Inhibitors of the F-Box Protein SKP2
    Shouksmith, Andrew E.
    Evans, Laura E.
    Tweddle, Deborah A.
    Miller, Duncan C.
    Willmore, Elaine
    Newell, David R.
    Golding, Bernard T.
    Griffin, Roger J.
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2015, 68 (04) : 660 - 679
  • [36] Current advances of small molecule E3 ligands for proteolysis-targeting chimeras design
    Mi, Dazhao
    Li, Yuzhan
    Gu, Haijun
    Li, Yan
    Chen, Yihua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 256
  • [37] Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
    Chiara Maniaci
    Scott J. Hughes
    Andrea Testa
    Wenzhang Chen
    Douglas J. Lamont
    Sonia Rocha
    Dario R. Alessi
    Roberto Romeo
    Alessio Ciulli
    Nature Communications, 8
  • [38] Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
    Maniaci, Chiara
    Hughes, Scott J.
    Testa, Andrea
    Chen, Wenzhang
    Lamont, Douglas J.
    Rocha, Sonia
    Alessi, Dario R.
    Romeo, Roberto
    Ciulli, Alessio
    NATURE COMMUNICATIONS, 2017, 8
  • [39] Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput Screening Assay
    Deschamps, Thibaut
    Waisner, Hope
    Dogrammatzis, Christos
    Roy, Anuradha
    Chacko, Shibin
    Perera, Chamani
    Prisinzano, Thomas E.
    Kalamvoki, Maria
    JOURNAL OF VIROLOGY, 2019, 93 (13)
  • [40] Design, synthesis and biological evaluation of small-molecule inhibitors of XIAP.
    Chen, JY
    Zaneta, NC
    Yang, CY
    Wang, GP
    Su, Q
    Xu, L
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U182 - U182
12345