Macula Densa Sensing and Signaling Mechanisms of Renin Release

被引：136

作者：

Peti-Peterdi, Janos ^{[1
,2
]}

Harris, Raymond C. ^{[3
]}

机构：

[1] Univ So Calif, Dept Physiol & Biophys, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Med, Zilkha Neurogenet Inst, Los Angeles, CA USA

[3] Vanderbilt Univ, Sch Med, Dept Med, Div Nephrol, Nashville, TN 37232 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 07期

关键词：

SUCCINATE RECEPTOR GPR91; NITRIC-OXIDE SYNTHASE; CYCLOOXYGENASE-2; EXPRESSION; PROSTAGLANDIN E-2; INHIBITION; KIDNEY; STIMULATION; SYSTEM; ADENOSINE; CELLS;

D O I：

10.1681/ASN.2009070759

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release.

引用

页码：1093 / 1096

页数：4

共 38 条

[1] Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric oxide synthase [J].

Beierwaltes, WH .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 272 (05) :R1359-R1364

[2] Macula densa cell signaling [J].

Bell, PD ;

Lapointe, JY ;

Peti-Peterdi, J .

ANNUAL REVIEW OF PHYSIOLOGY, 2003, 65 :481-500

[3] Angiotensin II attenuates renal cortical cyclooxygenase-2 expression [J].

Cheng, HF ;

Wang, JL ;

Zhang, MZ ;

Miyazaki, Y ;

Ichikawa, I ;

McKanna, JA ;

Harris, RC .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (07) :953-961

[4] Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride [J].

Cheng, HF ;

Wang, JL ;

Zhang, MZ ;

McKanna, JA ;

Harris, RC .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (05) :681-688

[5] Uric acid and cardiovascular risk [J].

Feig, Daniel I. ;

Kang, Duk-Hee ;

Johnson, Richard J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (17) :1811-1821

[6] Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney [J].

Fuson, AL ;

Komlosi, P ;

Unlap, TM ;

Bell, PD ;

Peti-Peterdi, J .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 285 (03) :F558-F564

[7] The renin-angiotensin system and diabetic nephropathy [J].

Gurley, Susan B. ;

Coffman, Thomas M. .

SEMINARS IN NEPHROLOGY, 2007, 27 (02) :144-152

[8] Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2 [J].

Hanner, Fiona ;

Chambrey, Regine ;

Bourgeois, Soline ;

Meer, Elliott ;

Mucsi, Istvan ;

Rosivall, Laszlo ;

Shull, Gary E. ;

Lorenz, John N. ;

Eladari, Dominique ;

Peti-Peterdi, Janos .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 294 (04) :F937-F944

[9] Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics [J].

Harding, P ;

Carretero, OA ;

Beierwaltes, WH .

JOURNAL OF HYPERTENSION, 2000, 18 (08) :1107-1113

[10] CYCLOOXYGENASE-2 IS ASSOCIATED WITH THE MACULA DENSA OF RAT-KIDNEY AND INCREASES WITH SALT RESTRICTION [J].

HARRIS, RC ;

MCKANNA, JA ;

AKAI, Y ;

JACOBSON, HR ;

DUBOIS, RN ;

BREYER, MD .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2504-2510

← 1 2 3 4 →