Validation of a simplified international prognostic score (IPS-3) in patients with advanced-stage classic Hodgkin lymphoma

被引：12

作者：

Hayden, Anna R. ^{[1
]}

Lee, Derrick G. ^{[2
,3
]}

Villa, Diego ^{[1
]}

Gerrie, Alina S. ^{[1
]}

Scott, David W. ^{[1
]}

Slack, Graham W. ^{[4
]}

Sehn, Laurie H. ^{[1
]}

Connors, Joseph M. ^{[1
]}

Savage, Kerry J. ^{[1
]}

机构：

[1] British Columbia Canc, Ctr Lymphoid Canc, Dept Med Oncol, Vancouver, BC, Canada

[2] St Francis Xavier Univ, Dept Math Stat & Comp Sci, Antigonish, NS, Canada

[3] BC Canc, Canc Control Res, Vancouver, BC, Canada

[4] British Columbia Canc Ctr Lymphoid Canc, Dept Pathol, Vancouver, BC, Canada

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 189卷 / 01期

关键词：

hodgkins lymphoma; prognostic factors; ABVD; international prognostic score; lymphoma; POSITRON-EMISSION-TOMOGRAPHY; METABOLIC TUMOR VOLUME; INTERIM; SURVIVAL; PREDICTS;

D O I：

10.1111/bjh.16293

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A novel prognostic score (IPS-3), comprised of only three of the seven IPS-7 indicators (age >= 45, stage IV, haemoglobin <105 g/l), was recently proposed as a simplified model for advanced-stage classic Hodgkin lymphoma (cHL). We aimed to validate this model in advanced-stage cHL patients treated with doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) in British Columbia. The estimated five-year freedom from progression (FFP) for scores of 0, 1, 2 and 3 were very similar to the original report at 84%, 76%, 72% and 68% respectively. The IPS-3 score is highly reproducible in this independent dataset and its simplicity makes it appealing for everyday clinical practice.

引用

页码：122 / 127

页数：6

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