TET mediated epigenetic regulation of iNKT cell lineage fate choice and function

被引：8

作者：

Tsagaratou, Ageliki ^{[1
,2
,3
]}

机构：

[1] La Jolla Inst Allergy & Immunol, 9420 Athena Circle, San Diego, CA 92037 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[3] Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA

来源：

MOLECULAR IMMUNOLOGY | 2018年 / 101卷

关键词：

iNKT cells; Lineage specification; Epigenetics; DNA methylation; 5; Hydroxymethylcytosine; TET proteins; DNA modifications; Histone marks; Chromatin accessibility; Gene expression; EMBRYONIC STEM-CELLS; KILLER T-CELLS; ACTIVE DNA DEMETHYLATION; HEMI-METHYLATED DNA; GAMMA-DELTA T; GENE-EXPRESSION; NKT CELLS; TRANSCRIPTIONAL REGULATION; SELF-RENEWAL; EFFECTOR FUNCTIONS;

D O I：

10.1016/j.molimm.2018.08.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the epigenetic players that regulate gene expression and orchestrate the iNKT cell lineage choices remain poorly understood. Here, we summarize recent advances in our understanding of epigenetic regulation of iNKT cell development and lineage choice. Particular emphasis is placed on DNA modifications and the Ten Eleven Translocation (TET) family of DNA demethylases.

引用

页码：564 / 573

页数：10

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