Ruthenium(II) complexes of 2-(2′-pyridyl)naphthoimidazole:: synthesis, characterization and DNA-binding studies

被引：28

作者：

Liu, Yun-Jun ^{[1
]}

Mei, Wen-Jie ^{[1
]}

Lu, Jia-Zheng ^{[1
]}

Zhao, Hao-Jie ^{[1
]}

He, Li-Xin ^{[1
]}

Wu, Fu-Hai ^{[2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2008年 / 61卷 / 20期

关键词：

ruthenuim(II) complex; DNA; thermal denaturation;

D O I：

10.1080/00958970802017653

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The perchlorate salts of two new ruthenium(II) complexes incorporating 2-(2'-pyridyl)naphthoimidazole are synthesized in good yield. Complexes [Ru(phen)2(PYNI)](2+) (phen = 1,10-phenanthroline) 1 and [Ru(dmp)2(PYNI)](2+) (dmp = 2,9-dimethyl-1,10-phenanthroline, PYNI = 2-(2'-pyridyl)naphthoimidazole) 2 are fully characterized by elemental analysis, FAB-MS, ES-MS, H-1 NMR and cyclic voltammetric methods. The DNA-binding behavior of the complexes have been studied by spectroscopic titration, viscosity measurements and thermal denaturation. Absorption titration and thermal denaturation studies reveal that these complexes are moderately strong binders of calf-thymus DNA (CT-DNA), with their binding constants spanning the range (2.73-5.35) 10(4) M-1. The experimental results show that 1 interacts with calf thymus DNA (CT-DNA) by intercalative mode, while 2 binds to CT-DNA by partial intercalation.

引用

页码：3213 / 3224

页数：12

共 55 条

[1] Rates of DNA-mediated electron transfer between metallointercalators [J].

Arkin, MR ;

Stemp, EDA ;

Holmlin, RE ;

Barton, JK ;

Hormann, A ;

Olson, EJC ;

Barbara, PF .

SCIENCE, 1996, 273 (5274) :475-480

[2] Synthesis, structure, redox activity and spectroscopic properties of ruthenium(II) complexes with 3,5-bis(benzothiazol-2-yl)pyrazole, 3,5-bis(benzimidazol-2-yl)pyrazole and 2,2′-bipyridine as co-ligands [J].

Baitalik, S ;

Flörke, U ;

Nag, K .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (05) :719-727

[3] BINDING MODES AND BASE SPECIFICITY OF TRIS(PHENANTHROLINE)RUTHENIUM(II) ENANTIOMERS WITH NUCLEIC-ACIDS - TUNING THE STEREOSELECTIVITY [J].

BARTON, JK ;

GOLDBERG, JM ;

KUMAR, CV ;

TURRO, NJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2081-2088

[4] STUDIES ON INTERACTION OF ANTHRACYCLINE ANTIBIOTICS AND DEOXYRIBONUCLEIC-ACID - EQUILIBRIUM BINDING-STUDIES ON INTERACTION OF DAUNOMYCIN WITH DEOXYRIBONUCLEIC-ACID [J].

CHAIRES, JB ;

DATTAGUPTA, N ;

CROTHERS, DM .

BIOCHEMISTRY, 1982, 21 (17) :3933-3940

[5]

CHAMBRON JC, 1985, NOUV J CHIM, V9, P527

[6] Binding mode of [ruthenium(II) (1,10-phenanthroline)(2)L](2+) with poly(dT*dA-dT) triplex. Ligand size effect on third-strand stabilization [J].

Choi, SD ;

Kim, MS ;

Kim, SK ;

Lincoln, P ;

Tuite, E ;

Norden, B .

BIOCHEMISTRY, 1997, 36 (01) :214-223

[7] VISCOSITY AND SEDIMENTATION STUDY OF SONICATED DNA-PROFLAVINE COMPLEXES [J].

COHEN, G ;

EISENBERG, H .

BIOPOLYMERS, 1969, 8 (01) :45-+

[8] SYNTHESIS AND STUDY OF MONONUCLEAR RUTHENIUM(II) COMPLEXES OF STERICALLY HINDERING DIIMINE CHELATES - IMPLICATIONS FOR THE CATALYTIC-OXIDATION OF WATER TO MOLECULAR-OXYGEN [J].

COLLIN, JP ;

SAUVAGE, JP .

INORGANIC CHEMISTRY, 1986, 25 (02) :135-141

[9] Scanning force microscopy of small ligand nucleic acid complexes: Tris(o-phenanthroline)ruthenium(II) as a test for a new assay [J].

Coury, JE ;

Anderson, JR ;

McFailIsom, L ;

Williams, LD ;

Bottomley, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (16) :3792-3796

[10]

Deng H., 2003, J CHEM SOC DA, P325

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