HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences

被引：0
|
作者：
Mikasi, Sello Given [1 ]
Isaacs, Darren [2 ]
Ikomey, George Mondinde [3 ]
Shimba, Henerico [1 ,4 ]
Cloete, Ruben [3 ]
Jacobs, Graeme Brendon [1 ]
机构：
[1] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Pathol, Div Med Virol, ZA-7505 Cape Town, South Africa
[2] Univ Western Cape, South African Natl Bioinformat Inst, South African Med Res Council, Bioinformat Unit, Cape Town, South Africa
[3] Univ Yaounde I, Fac Med & Biomed Sci, Ctr Study & Control Communicable Dis, Yaounde, Cameroon
[4] Bugando Med Ctr, Mwanza, Tanzania
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2021年 / 37卷 / 01期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
HIV-1; integrase; resistance; Cameroon; diversity; CRF02_AG; DOLUTEGRAVIR; RALTEGRAVIR;
D O I：
10.1089/aid.2020.0022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences have INSTI accessory RAMs. HIV-1 CRF02_AG was the predominant subtype (44.7%) in this study analyses. The occurrence of INSTI RAMs among the sequences at baseline needs to be monitored carefully.
引用
收藏
页码：54 / 56
页数：3
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