Therapeutic Applications of the CRISPR-Cas System

被引:6
|
作者
Kang, Kyungmin [1 ]
Song, Youngjae [1 ]
Kim, Inho [1 ]
Kim, Tae-Jung [2 ]
机构
[1] Catholic Univ Korea, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea
[2] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Hosp Pathol, 10,63 Ro, Seoul 07345, South Korea
来源
BIOENGINEERING-BASEL | 2022年 / 9卷 / 09期
基金
新加坡国家研究基金会;
关键词
CRISPR-Cas9; Cas13; Immunotherapy; gene editing; cell therapy;
D O I
10.3390/bioengineering9090477
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications.
引用
收藏
页数:15
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