Haploidentical bone marrow transplantation in Mexico

Haploidentical hematopoietic cell transplantation using CD34+ cells depleted of T lymphocytes by the CliniMACS is a treatment for hematological malignancy. We report on four Mexican children, three with acute lymphocytic leukemia and one with chronic myelocytic leukemia, who was transplanted with 12 x 106?CD34+?stem cells/kg body weight (98% of purity) with a follow-up of $9{\textstyle{{1} \over {2}}}$ years. The engraftment was successful in three of the four children. All showed cytomegalovirus reactivation, and one died because of graft rejection and infectious complication. The risk of infections was a major problem. Pediatr Blood Cancer 2012; 59: 950952. (C) 2012 Wiley Periodicals, Inc.