Schilancitrilactones A-C: Three Unique Nortriterpenoids from Schisandra lancifolia

被引：45

作者：

Luo, Xiao ^{[1
,2
]}

Shi, Yi-Ming ^{[1
,4
]}

Luo, Rong-Hua ^{[3
]}

Luo, Shi-Hong ^{[1
]}

Li, Xiao-Nian ^{[1
]}

Wang, Rui-Rui ^{[3
]}

Li, Sheng-Hong ^{[1
]}

Zheng, Yong-Tang ^{[3
]}

Du, Xue ^{[1
]}

Xiao, Wei-Lie ^{[1
]}

Pu, Jian-Xin ^{[1
]}

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China

[2] Henan Univ Tradit Chinese Med, Zhengzhou 450008, Henan, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[4] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 05期

关键词：

LANCIFODILACTONE-G; STEREOCONTROLLED SYNTHESIS; NATURAL-PRODUCTS; RING; ARISANENSIS; SKELETON; LEAVES; FRUITS; STEMS; CORE;

D O I：

10.1021/ol300099e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

hree unique nortriterpenoids, schilancitrilactones A-C (1-3), were isolated from the stems of Schisandra lancifolia. Compound 1 possesses a 5/517/5/5/5-fused hexacyclic ring system with a C-29 backbone, while 2 and 3 feature a C-27 skeleton with a 5/7/5/5/5-fused pentacyclic ring system. Their absolute stereochemistries were established by CD and single-crystal X-ray diffraction experiments. Compound 3 showed anti-HIV-1 activity with an EC50 value of 27.54 mu g/mL, and 1 exhibited antifeedant activity at 15.73 mu g/cm(2).

引用

页码：1286 / 1289

页数：4

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