Natural Products from Deep-Sea-Derived Fungi - A New Source of Novel Bioactive Compounds?

被引：46

作者：

Daletos, Georgios ^{[1
]}

Ebrahim, Weaam ^{[1
,2
]}

Ancheeva, Elena ^{[1
]}

El-Neketi, Mona ^{[2
]}

Song, Weiguo ^{[3
]}

Lin, Wenhan ^{[4
]}

Proksch, Peter ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Fukang Pharma North East Dongwaihuan Rd, Shouguang City 262700, Peoples R China

[4] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2018年 / 25卷 / 02期

关键词：

Deep-sea fungi; extremophiles; natural products; bioactive metabolites; drug discovery; bioprospecting; PENICILLIUM SP; TETRANORLABDANE DITERPENOIDS; SECONDARY METABOLITES; HYBRID POLYKETIDES; A-C; ALKALOIDS; DERIVATIVES; ANALOGS; SP; HAENAMINDOLE;

D O I：

10.2174/0929867324666170314150121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above. Results: This review summarizes the new and/or bioactive compounds reported from deep-sea-derived fungi in the last six years (2010 - October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities.

引用

页码：186 / 207

页数：22

共 111 条

[1] Cultivating the uncultured: limits, advances and future challenges [J].