Success with lifestyle monotherapy in youth with new-onset type 2 diabetes

被引：26

作者：

Wittmeier, Kristy D. M. ^{[1
,3
]}

Wicklow, Brandy A. ^{[2
,3
]}

Sellers, Elizabeth A. C. ^{[2
,3
]}

Griffith, Angella T. R. ^{[3
]}

Dean, Heather J. ^{[2
,3
]}

McGavock, Jonathan M. ^{[2
,3
]}

机构：

[1] Univ Manitoba, Dept Physiol, Hlth Sci Ctr, Winnipeg, MB, Canada

[2] Univ Manitoba, Dept Pediat & Child Hlth, Hlth Sci Ctr, Fac Med, Winnipeg, MB R3T 2N2, Canada

[3] Manitoba Inst Child Hlth, John Buhler Res Ctr, Winnipeg, MB R3E 3P4, Canada

来源：

PAEDIATRICS & CHILD HEALTH | 2012年 / 17卷 / 03期

基金：

加拿大健康研究院;

关键词：

Glycosylated hemoglobin; Lifestyle; Treatment; Type; 2; diabetes; Youth; GLYCEMIC CONTROL; FOLLOW-UP; MELLITUS; CHILDREN;

D O I：

10.1093/pch/17.3.129

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BACKGROUND: Evidence is lacking to support the efficacy of lifestyle modification as first-line therapy in the clinical management of type 2 diabetes mellitus (T2DM) in adolescents. METHODS: A retrospective chart review of youth diagnosed with T2DM between 1999 and 2008 was conducted. The authors describe the percentage of youth presenting with glycosylated hemoglobin (HbA(1c)) of <9% who achieved/maintained target glycemic control (HbA(1c) <= 7.0%) with lifestyle monotherapy during the year following diagnosis. RESULTS: Among the 275 youth with T2DM, 38% (n=104) presented with an HbA(1c) <9% and were prescribed lifestyle monotherapy at diagnosis. Of the 80 youth who had sufficient follow-up data over 12 months, 54% successfully maintained target glycemic control solely with lifestyle management. The mean HbA(1c) score at diagnosis was lower in youth who where successful on lifestlye monotherapy compared with those who were not successful. CONCLUSIONS: A significant proportion of youth newly diagnosed with T2DM presenting with an HbA(1c) <9% effectively achieved/maintained target glycemic control with lifestyle recommendations alone for 12 months.

引用

页码：129 / 132

页数：4

共 19 条

[1] Type 2 Diabetes, Medication-Induced Diabetes, and Monogenic Diabetes in Canadian Children A prospective national surveillance study [J].

Amed, Shazhan ;

Dean, Heather J. ;

Panagiotopoulos, Constadina ;

Sellers, Elizabeth A. C. ;

Hadjiyannakis, Stasia ;

Laubscher, Tessa A. ;

Dannenbaum, David ;

Shah, Baiju R. ;

Booth, Gillian L. ;

Hamilton, Jill K. .

DIABETES CARE, 2010, 33 (04) :786-791

[2]

Amer Diabet Assoc, 2012, DIABETES CARE, V35, pS64, DOI [10.2337/dc19-S002, 10.2337/dc12-S064, 10.2337/dc23-S002, 10.2337/dc09-S062, 10.2337/dc18-S002]

[3]

[Anonymous], 2008, Can J Diabetes, V32, pS1, DOI DOI 10.1503/CMAJ.080554

[4] Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus -: A meta-analysis of controlled clinical trials [J].

Boulé, NG ;

Haddad, E ;

Kenny, GP ;

Wells, GA ;

Sigal, RJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (10) :1218-1227

[5]

Espeland M, 2007, DIABETES CARE, V30, P1374

[6] Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents [J].

Grinstein, G ;

Muzumdar, R ;

Aponte, L ;

Vuguin, P ;

Saenger, P ;

DiMartino-Nardi, J .

HORMONE RESEARCH, 2003, 60 (03) :121-126

[7]

Haymond M, 2007, PEDIATR DIABETES, V8, P74

[8] Early-onset insulin-resistant diabetes in obese Caucasians has features of typical type 2 diabetes, but 3 decades earlier [J].

McQuaid, S ;

O'Gorman, DJ ;

Yousif, O ;

Yeow, TP ;

Rahman, Y ;

Gasparro, D ;

Pacini, G ;

Nolan, JJ .

DIABETES CARE, 2005, 28 (05) :1216-1218

[9]

Peterson K, 2007, AM FAM PHYSICIAN, V76, P658

[10] Type 2 diabetes in children and adolescents in a 2-year follow-up: Insufficient adherence to diabetes centers [J].

Reinehr, Thomas ;

Schober, Edith ;

Roth, Christian L. ;

Wiegand, Susanna ;

Holl, Reinhard .

HORMONE RESEARCH, 2008, 69 (02) :107-113

← 1 2 →