Outcomes of Hepatoblastoma in the Indian Context

被引：9
作者：
Arora, R. S. [1 ]
机构：
[1] Alder Hey Childrens Hosp, Liverpool L12 2AP, Merseyside, England
来源：
INDIAN PEDIATRICS | 2012年 / 49卷 / 04期
关键词：
Hepatoblastoma; India; Outcome; Prognosis; Survival; PEDIATRIC-ONCOLOGY; EXPERIENCE; DOXORUBICIN; CANCER; CISPLATIN; SURGERY;
D O I：
10.1007/s13312-012-0037-1
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A comprehensive review and critical appraisal of published and grey literature was undertaken to identify current treatment practices and outcomes of children with hepatoblastoma in India. Eight single-centre studies with 157 patients (range five to 36 patients in each study) were included. Pre-operative chemotherapy (mainly cisplatin and doxorubicin) followed by surgical resection and additional chemotherapy was the usual practice. There was no stratification of treatment by risk group in any of the studies. The median event-free survival ranged from 33-100%. The two main reasons for treatment failure were treatment-related mortality (0-50%) and progression of disease (0-30%).
引用
收藏
页码：307 / 309
页数：3
相关论文
共 17 条
  • [1] Agarwala S, 2009, PEDIATR BLOOD CANCER, V53, P717
  • [2] Agarwala S, 2007, PEDIATR BLOOD CANCER, V49, P401
  • [3] Understanding Refusal and Abandonment in the Treatment of Childhood Cancer
    Arora, R. S.
    Pizer, B.
    Eden, T.
    [J]. INDIAN PEDIATRICS, 2010, 47 (12) : 1005 - 1010
  • [4] Cyriac Sanju, 2011, J Indian Assoc Pediatr Surg, V16, P11, DOI 10.4103/0971-9261.74514
  • [5] EXELBY PR, 1975, J PEDIATR SURG, V10, P329
  • [6] Mehta P, 2007, PEDIATR BLOOD CANCER, V49, P535
  • [7] Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group
    Ortega, JA
    Douglass, EC
    Feusner, JH
    Reynolds, M
    Quinn, JJ
    Finegold, MJ
    Haas, JE
    King, DR
    Liu-Mares, W
    Sensel, MG
    Krailo, MD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (14) : 2665 - 2675
  • [8] Cisplatin versus Cisplatin plus Doxorubicin for Standard-Risk Hepatoblastoma
    Perilongo, Giorgio
    Maibach, Rudolf
    Shafford, Elisabeth
    Brugieres, Laurence
    Brock, Penelope
    Morland, Bruce
    de Camargo, Beatriz
    Zsiros, Jozsef
    Roebuck, Derek
    Zimmermann, Arthur
    Aronson, Daniel
    Childs, Margaret
    Widing, Eva
    Laithier, Veronique
    Plaschkes, Jack
    Pritchard, Jon
    Scopinaro, Marcello
    MacKinlay, Gordon
    Czauderna, Piotr
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (17) : 1662 - 1670
  • [9] Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: A successful approach - Results of the first prospective study of the international society of pediatric oncology
    Pritchard, J
    Brown, J
    Shafford, E
    Perilongo, G
    Brock, P
    Dicks-Mireaux, C
    Keeling, J
    Phillips, A
    Vos, A
    Plaschkes, J
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (22) : 3819 - 3828
  • [10] Rao Sanjay, 2011, J Indian Assoc Pediatr Surg, V16, P2, DOI 10.4103/0971-9261.74512
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