The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

被引:21
作者
Khaled, Shimaa S. [1 ]
Soliman, Hanan A. [1 ]
Abdel-Gabbar, Mohammed [1 ]
Ahmed, Noha A. [2 ]
Attia, Kandil Abdel Hai Ali [3 ]
Mahran, Hesham A. [4 ,5 ]
El-Nahass, El-Shaymaa [6 ]
Ahmed, Osama M. [2 ]
机构
[1] Beni Suef Univ, Fac Sci, Biochem Dept, Bani Suwayf 62521, Egypt
[2] Beni Suef Univ, Fac Sci, Physiol Div, Zool Dept, Bani Suwayf 62521, Egypt
[3] Jazan Univ, Coll Appl Med Sci, Clin Nutr Dept, Box 114, Jazan 45142, Saudi Arabia
[4] Jazan Univ, Coll Publ Hlth & Trop Med, Hlth Informat Dept, Box 114, Jazan 45142, Saudi Arabia
[5] Beni Suef Univ, Fac Vet Med, Hyg,Zoonosis & Epidemiol Dept, Bani Suwayf, Egypt
[6] Beni Suef Univ, Fac Vet Med, Dept Pathol, Bani Suwayf 62521, Egypt
关键词
CISPLATIN-INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; FLAVONOID NARINGENIN; CANCER-CELLS; IN-VITRO; ACID; DOXORUBICIN; QUERCETIN; TOXICITY; TAXOL;
D O I
10.1155/2022/8739815
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure.
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页数:11
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