y Raynaud's phenomenon

被引：51

作者：

Herrick, Ariane L. ^{[1
]}

Wigley, Fredrick M. ^{[2
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Musculoskeletal & Dermatol Sci, Salford Royal NHS Fdn Trust, Manchester, Lancs, England

[2] Johns Hopkins Sch Med, Div Rheumatol, Dept Med, Baltimore, MD USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2020年 / 34卷 / 01期

关键词：

Raynaud's phenomenon; Connective tissue disease; Systemic sclerosis; Pathogenesis; Autoantibodies; Capillaroscopy; Treatment; 2013 CLASSIFICATION CRITERIA; CONNECTIVE-TISSUE DISEASE; SYSTEMIC-SCLEROSIS; DIGITAL ULCERS; DOUBLE-BLIND; CLINICAL-TRIALS; RHEUMATOLOGY/EUROPEAN LEAGUE; INFRARED THERMOGRAPHY; NAILFOLD CAPILLARIES; PHENOMENON SECONDARY;

D O I：

10.1016/j.berh.2019.101474

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Raynaud's phenomenon (RP) is common, affecting approximately 5% of the population, and is important to the rheumatologist because it is often the presenting symptom of connective tissue disease, especially of systemic sclerosis (SSc)-spectrum disorders. RP therefore provides a window of opportunity for early diagnosis. When RP is associated with SSc it is particularly challenging to treat. This review begins with a discussion of some of the recent advances in our understanding of the pathogenesis of RP: it is through increased understanding of the complex pathophysiology of RP that we are most likely to develop new therapies. The following questions are then addressed (with three clinical scenarios demonstrating key principles of assessment and management): 1. How can we predict underlying connective tissue disease in the patient presenting with Raynaud's? 2. How can we measure severity of Raynaud's? 3. What are the latest advances in treatment of connective tissue disease-related digital vasculopathy? (C) 2019 Published by Elsevier Ltd.

引用

页数：21

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