Fatty acid synthase (FAS)-catalyzed endogenous fatty acid metabolism regulates Her-2/neu (erbB-2) oncogene expression via malonyl-coenzyme-a-dependent expression of the Ets protein polyomavirus enhancer activator 3 (PEA3), a transcriptional repressor of Her-2/neu promoter activity in cancer cells.

被引：0

作者：

Menendez, JA

Papadimitropoulou, A

Vellon, L

Colomer, R

Lupu, R

机构：

[1] Evanston NW Healthcare, Evanston, IL USA

[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Hosp Univ Dr Josep Trueta, Inst Catala Oncol, Girona, Catalonia, Spain

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2005年 / 94卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：S183 / S183

页数：1

共 13 条

[1] Cancer fatty acid metabolism regulates Her-2/neu (erbB-2) oncogene expression via formation of "PEA3 transcription factor-PEA3 DNA binding site" complexes on the Her-2/neu gene promoter
Menendez, Javier A., Sr.
Papadimitropoulou, Adriana
Vellon, Luciano
Lupu, Ruth
CANCER RESEARCH, 2006, 66 (08)
[2] Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
Menendez, JA
Vellon, L
Mehmi, I
Oza, BP
Ropero, S
Colomer, R
Lupu, R
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) : 10715 - 10720
[3] A genomic explanation linking breast cancer, "Mediterranean diet" and olive oil: Olive oil's monounsaturated fatty acid oleic acid transcriptionally regulates the co-ordinate expression of Fatty Acid Synthase (Oncogenic antigen-519), Her-2/neu (erbB-2) and PEA3 genes in breast cancer cells.
Menendez, Javier A., Sr.
Papadimitropoulou, Adriana
Vellon, Luciano
Lupu, Ruth
CANCER RESEARCH, 2006, 66 (08)
[4] Inhibition of fatty acid synthase by amentoflavone suppresses HER2/neu (erbB2) oncogene expression in breast cancer cells
Chang, E.
Lee, J.
Lee, M.
Cha, E.
Sul, J.
Byun, W.
EJC SUPPLEMENTS, 2010, 8 (03): : 178 - 178
[5] Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erb B-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin™) in breast cancer cells with Her-2/neu oncogene amplification
Menendez, JA
Vellon, L
Colomer, R
Lupu, R
ANNALS OF ONCOLOGY, 2005, 16 (03) : 359 - 371
[6] Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation
Menendez, JA
Mehmi, I
Verma, VA
Teng, PK
Lupu, R
MOLECULAR CARCINOGENESIS, 2004, 41 (03) : 164 - 178
[7] A genomic explanation connecting "Mediterranean diet", olive oil and cancer:: Oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells
Menendez, Javier A.
Papadimitropoulou, Adriana
Vellon, Luciano
Lupu, Ruth
EUROPEAN JOURNAL OF CANCER, 2006, 42 (15) : 2425 - 2432
[8] Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells
Lee, Jin Sun
Sul, Ji Young
Park, Jun Beom
Lee, Myung Sun
Cha, Eun Young
Song, In Sang
Kim, Je Ryong
Chang, Eil Sung
PHYTOTHERAPY RESEARCH, 2013, 27 (05) : 713 - 720
[9] Development of a high-sensitive antibody-based protein array system that quantitatively detects serum Fatty Acid Synthase (sFASN) in breast cancer: correlation with Her-2/neu (erbB-2) expression and trastuzumab efficacy
Menendez, J. A.
Vazquez-Martin, A.
Colomer, R.
EJC SUPPLEMENTS, 2006, 4 (12): : 44 - 44
[10] Exogenous supplementation with ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells
Menendez, JA
Lupu, R
Colomer, R
EUROPEAN JOURNAL OF CANCER PREVENTION, 2005, 14 (03) : 263 - 270

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