Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis

被引：5
|
作者：
Omar, Shaheed, V [1 ]
Joseph, Lavania [1 ]
Said, Halima M. [1 ,2 ]
Ismail, Farzana [1 ,3 ]
Ismail, Nabila [1 ]
Gwala, Thabisile L. [1 ]
Ismail, Nazir A. [1 ,3 ]
机构：
[1] Natl Hlth Lab Serv, Natl Inst Communicable Dis, World Hlth Org TB Supranatl Reference Lab Network, Ctr TB, Johannesburg, South Africa
[2] Univ Free State, Dept Med Microbiol, Bloemfontein, South Africa
[3] Univ Pretoria, Dept Med Microbiol, Pretoria, South Africa
来源：
AFRICAN JOURNAL OF LABORATORY MEDICINE | 2019年 / 8卷 / 01期
关键词：
RIFAMPICIN RESISTANCE; SUSCEPTIBILITY; MUTATIONS; COMPLEX; SYSTEM;
D O I：
10.4102/ajlm.v8i1.801
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.
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页数：5
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