Ir-Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo

被引：8
作者：
Wang, Chenchen [1 ]
Zhai, Tianli [1 ]
Liu, Jie [2 ,3 ]
Yang, Hong [1 ]
Sun, Yun [4 ,5 ]
Zhou, Zhiguo [1 ]
Zhao, Qiang [6 ,7 ]
Yang, Shiping [1 ]
机构：
[1] Shanghai Normal Univ, Coll Chem & Mat Sci, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China
[2] Univ Shanghai Sci & Technol, Inst Bismuth Sci, Shanghai 200093, Peoples R China
[3] Univ Shanghai Sci & Technol, Coll Sci, Shanghai 200093, Peoples R China
[4] Fudan Univ, Canc Hosp, Dept Res & Dev, Shanghai 201321, Peoples R China
[5] Fudan Univ, Dept Nucl Med, Canc Hosp, Shanghai Proton & Heavy Ion Ctr, Shanghai 201321, Peoples R China
[6] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect Informat Displays, Nanjing 210023, Peoples R China
[7] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210023, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 46期
基金：
中国国家自然科学基金;
关键词：
X-RAY; PHOTODYNAMIC THERAPY; RADIOTHERAPY; CELLS; ASSAY;
D O I：
10.1039/d0cc02641g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a bimetallic complex [Ir4Ho2(pq)(8)(H(2)dcbpy)(4)(OAc)(2)] (denoted as Ir4Ho2, pq = 2-phenylquinoline, H(2)dcppy = 2,2'-bipyridine-3,3'-dicarboxylic acid) and its application for radiotherapy/radiodynamic therapy (RT/RDT). In a tumor xenograft mouse model, Ir4Ho2 exerted a tumor-suppressive effect through efficient low-dose RT/RDT.
引用
收藏
页码：6193 / 6196
页数：4
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