Evaluation of a novel commercial rapid test for dengue diagnosis based on specific IgA detection

被引：10
作者：
de la Cruz Hernandez, Sergio Isaac [1 ,2 ]
Gonzalez Mateos, Silvia [2 ]
Flores Aguilar, Hilario [3 ]
Lopez Martinez, Irma [2 ]
Alpuche Aranda, Celia [4 ]
Ludert, Juan E. [1 ]
Maria del Angel, Rosa [1 ]
机构：
[1] CINVESTAV, IPN, Ctr Invest Estudios Avanzados, Dept Infectom & Patogenesis Mol,Inst Politecn Nac, Mexico City 14000, DF, Mexico
[2] CINVESTAV, IPN, Ctr Invest Estudios Avanzados, Dept Virol,Inst Politecn Nacl, Mexico City 14000, DF, Mexico
[3] CINVESTAV, IPN, Ctr Invest Estudios Avanzados, Dept Immunol & Immunogenet,Inst Politecn Nacl, Mexico City 14000, DF, Mexico
[4] CINVESTAV, IPN, Ctr Invest Estudios Avanzados, Direcc Gen Adjunta,InDRE, Mexico City 14000, DF, Mexico
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2012年 / 72卷 / 02期
关键词：
Dengue; Dengue diagnosis; ASSURE (R) IgA; Immunochromatography; LINKED-IMMUNOSORBENT-ASSAY; IMMUNE-RESPONSE; PROTEIN NS1; VIRUS; ANTIGEN; SERUM; KINETICS; SENSITIVITY; ANTIBODIES; SEROTYPE;
D O I：
10.1016/j.diagmicrobio.2011.11.002
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The performance of the novel commercial test ASSURE (R) Dengue IgA Rapid test (MP Diagnostics) was evaluated using a panel of 172 sera collected from dengue patients and 47 sera from healthy blood donors. The overall specificity and sensitivity were 85.1% and 61.0%, respectively. However, the positivity rate for IgA went from 33.3% for sera collected the same day of fever onset to 81.2% for sera collected 5 days after fever onset. Infections with serotype 2 viruses were detected more efficiently than those with serotype 1 viruses, and no sera from infections with serotypes 3 and 4 were available. In addition, the kit was twice more efficient at detecting secondary infections than at detecting primary infections. Finally, the ASSURE (R) test showed good repeatability and reproducibility. The results of this study suggest that the ASSURE (R) Dengue IgA Rapid test may become a useful and easy-to-use test for early dengue diagnosis. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：150 / 155
页数：6
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