Indole Alkaloids and Quassinoids from the Stems of Brucea mollis

被引：111

作者：

Chen, Hui ^{[1
,2
]}

Bai, Jian ^{[1
,2
]}

Fang, Zhen-Feng ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Xu, Song ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Ren, Jin-Hong ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Si, Yi-Kang ^{[1
,2
]}

Chen, Xiao-Guang ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 11期

关键词：

CONSTITUENTS; GLYCOSIDES;

D O I：

10.1021/np200712y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis. The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra. The absolute configuration of the known compound 9 was determined by using Mo-2(OAc)(4)-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC50 values of 3.00-5.81 mu M.

引用

页码：2438 / 2445

页数：8

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