Commercial Synthesis of (S,S)-Reboxetine Succinate: A Journey To Find the Cheapest Commercial Chemistry for Manufacture

被引：18

作者：

Hayes, Stewart T. ^{[1
]}

Assaf, Georges ^{[1
]}

Checksfield, Graham ^{[1
]}

Cheung, Chi ^{[1
]}

Critcher, Doug ^{[1
]}

Harris, Laurence ^{[1
]}

Howard, Roger ^{[1
]}

Mathew, Suju ^{[1
]}

Regius, Christian ^{[1
]}

Scotney, Gemrna ^{[1
]}

Scott, Adam ^{[1
]}

机构：

[1] Pfizer Inc, Sandwich Labs, Chem Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2011年 / 15卷 / 06期

关键词：

D O I：

10.1021/op200181f

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.

引用

页码：1305 / 1314

页数：10

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