Solubility and thermodynamic function of apremilast in different (Transcutol plus water) cosolvent mixtures: Measurement, correlation and molecular interactions

被引：15
|
作者：
Shakeel, Faiyaz [1 ,2 ]
Haq, Nazrul [1 ]
Alanazi, Fars K. [1 ]
Alsarra, Ibrahim A. [1 ]
机构：
[1] King Saud Univ, Dept Pharmaceut, Coll Pharm, Kayyali Chair Pharmaceut Ind, POB 2457, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, CEBR, POB 2460, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2017年 / 56卷
关键词：
Apremilast; Activity coefficient; Cosolvent mixture; Solubility; Thermodynamics; JOUYBAN-ACREE MODEL; (2Z)-N-CYCLOHEXYL-2-(3-HYDROXYBENZYLIDINE) HYDRAZINE CARBOTHIOAMIDE; DIFFERENT PURE SOLVENTS; PEG 400+WATER MIXTURES; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; DIFFERENT TEMPERATURES; 338.15; K; DISSOLUTION THERMODYNAMICS; NEAT SOLVENTS;
D O I：
10.1016/j.jiec.2017.07.002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of apremilast (APM) in different "Transcutole + water" cosolvent mixtures was determined and correlated at "T = 298.2 K-318.2 K" and 'p = 0.1 MPa'. The experimental solubilities of APM were determined and correlated with "Apelblat, van't Hoff, Yalkowsky and Jouyban-Acree equations". The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 x 10(-2) at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. "Apparent thermodynamic analysis" showed an "endothermic and entropy-driven dissolution" of APM. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：99 / 107
页数：9
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