LARVICIDAL ACTIVITY AGAINST MOSQUITO OF BIS-(4-BENZYLIDENE-3-METHYL-1H-PYRAZOL-5(4H)-ONE)-COPPER (II) & BIS-(1,3-CYCLOHEXANEDIONE)-COPPER (II) COMPLEXES : A COMPARATIVE STUDY

Copper exhibits considerable biochemical action either as an essential trace metal or as a constituent of various exogenously administered compounds in humans. In its former role it is bound to ceruloplasmin, albumin, and other proteins, while in its latter it is bound to ligands of various types forming complexes that interact with biomolecules, mainly proteins and nucleic acids. The multifaceted role of copper in biological systems is demonstrated by several studies. In particular the involvement of copper in human diseases has been described from a medicinal-chemical and a biochemical view focusing on the molecular physiology of Cu transport.Current interest in Cu complexes is stemming from their potential use as antimicrobial, antiviral, anti-inflammatory, antitumor agents, enzyme inhibitors, or chemical nucleases. Markedly, the biochemical action of Cu complexes with non-steroidal anti-inflammatory drugs (NSAIDs) has been studied. Numerous Cu (II) complexes of NSAIDs showing enhanced anti-inflammatory and antiulcerogenic activity, as well as reduced gastrointestinal toxicity compared to the complexed drug, have been prepared and structurally characterized.