APOE, MTHFR, LDLR and ACE Polymorphisms Among Angami and Lotha Naga Populations of Nagaland, India

被引：4

作者：

Murry, Benrithung ^{[1
]}

Vakha, Neikethono ^{[1
]}

Achoubi, Nongthombam ^{[1
]}

Sachdeva, M. P. ^{[1
]}

Saraswathy, K. N. ^{[1
]}

机构：

[1] Univ Delhi, Dept Anthropol, Mol Lab, Delhi 110007, India

来源：

JOURNAL OF COMMUNITY HEALTH | 2011年 / 36卷 / 06期

关键词：

Gene polymorphisms; Prevalence; India; ANGIOTENSIN-CONVERTING ENZYME; METHYLENETETRAHYDROFOLATE-REDUCTASE GENE; APOLIPOPROTEIN-E POLYMORPHISM; PLASMA TOTAL HOMOCYSTEINE; INDEPENDENT RISK-FACTORS; CORONARY-ARTERY-DISEASE; INSERTION/DELETION POLYMORPHISM; ALZHEIMERS-DISEASE; C677T MUTATION; ALLELE FREQUENCIES;

D O I：

10.1007/s10900-011-9397-z

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Several common polymorphisms in the ApoE, ACE, MTHFR and LDLR genes have been implicated in the pathogenesis of common complex diseases across world populations. This study investigates the prevalence of five known and clinically important common polymorphisms in Angami and Lotha Naga populations. A total of 112 unrelated healthy volunteers (52 Lotha Nagas and 60 Angami Nagas) participated in the study. All the five genes were found to be polymorphic in the studied populations. The Lotha Nagas displayed higher mutant allele frequencies than the Angami Nagas except for the T allele frequency of the AvaII polymorphism of the LDLR gene, though chi square did not reveal any significant population differences by genotypes. In view of the relatively high mutant allele frequencies in both the populations, they are likely to be at a high risk of developing various complex diseases as they shift from an active and rigorous lifestyle to a more sedentary one.

引用

页码：975 / 985

页数：11