Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

Objective To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (>= 1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.