Natural History of the Electrocardiographic Pattern of Early Repolarization in Ambulatory Patients

被引:21
作者
Adhikarla, Chandana [1 ]
Boga, Madhavi [1 ]
Wood, Alexander D. [1 ,3 ]
Froelicher, Victor F. [1 ,2 ]
机构
[1] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA
[2] Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA
[3] Univ Bath, Bath BA2 7AY, Avon, England
关键词
D O I
10.1016/j.amjcard.2011.07.055
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although it is known that the electrocardiographic pattern of early repolarization (ER) occurs most commonly in healthy young bradycardic men, its natural history is uncertain. We considered initial electrocardiograms (ECGs) at rest from 29,281 ambulatory patients recorded from 1987 through 1999 at Veterans Affairs Palo Alto Hospital. With PR interval as the isoelectric line and amplitude criterion as >0.1 mV ER was identified when any of the following fulfilled the amplitude criterion: ST-segment elevation at the end of the QRS duration, J waves as an upward deflection, and slurs as delay on the R wave downstroke. The first 250 ECGs with the greatest ER increase were selected and the database was searched for an ECG >5 months later. Of the 250 patients selected with the greatest amplitude of ER 6 were excluded for electrocardiographic abnormalities, leaving 244 subjects, of whom 122 had another ECG >= 5 months later. Their average age was 42 +/- 10 years and average time from the first to second ECG was 10 years. Of the 122 patients 47 (38%) retained ER, whereas most (62%) no longer fulfilled the amplitude criterion. There were no significant differences in heart rate or time interval between ECGs. In conclusion, the electrocardiographic pattern of ER was lost over 10 years in more than half of this young clinical cohort and the loss was not caused by higher heart rate, longer time between ECGs, decrease in R-wave amplitude, death, acute disease, or alterations in electrocardiographic diagnostic characteristics. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;108:1831-1835)
引用
收藏
页码:1831 / 1835
页数:5
相关论文
共 12 条
  • [1] Brugada syndrome - Report of the second consensus conference - Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
    Antzelevitch, C
    Brugada, P
    Borggrefe, M
    Brugada, J
    Brugada, R
    Corrado, D
    Gussak, I
    LeMarec, H
    Nademanee, K
    Riera, ARP
    Shimizu, W
    Schulze-Bahr, E
    Tan, H
    Wilde, A
    [J]. CIRCULATION, 2005, 111 (05) : 659 - 670
  • [2] The early repolarization syndrome is a variant of normal - Reply
    Boineau, John P.
    [J]. JOURNAL OF ELECTROCARDIOLOGY, 2007, 40 (05) : 392 - 392
  • [3] BOINEAU JP, 2007, J ELECTROCARDIOGR S, V40
  • [4] SPATIAL VECTOR ELECTROCARDIOGRAPHY - THE CLINICAL CHARACTERISTICS OF S-T-VECTOR AND T-VECTOR
    GRANT, RP
    ESTES, EH
    DOYLE, JT
    [J]. CIRCULATION, 1951, 3 (02) : 182 - 197
  • [5] Sudden cardiac arrest associated with early repolarization
    Haissaguerre, Michel
    Derval, Nicolas
    Sacher, Frederic
    Jesel, Laurence
    Deisenhofer, Isabel
    de Roy, Luc
    Pasquie, Jean-Luc
    Nogami, Akihiko
    Babuty, Dominique
    Yli-Mayry, Sinikka
    De Chillou, Christian
    Scanu, Patrice
    Mabo, Philippe
    Matsuo, Seiichiro
    Probst, Vincent
    Le Scouarnec, Solena
    Defaye, Pascal
    Schlaepfer, Juerg
    Rostock, Thomas
    Lacroix, Dominique
    Lamaison, Dominique
    Lavergne, Thomas
    Aizawa, Yoshifusa
    Englund, Anders
    Anselme, Frederic
    O'Neill, Mark
    Hocini, Meleze
    Lim, Kang Teng
    Knecht, Sebastien
    Veenhuyzen, George D.
    Bordachar, Pierre
    Chauvin, Michel
    Jais, Pierre
    Coureau, Gaelle
    Chene, Genevieve
    Klein, George J.
    Clementy, Jacques
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (19) : 2016 - 2023
  • [6] LONG-TERM EVALUATION OF EARLY REPOLARIZATION SYNDROME (NORMAL VARIANT RS-T SEGMENT ELEVATION)
    KAMBARA, H
    PHILLIPS, J
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1976, 38 (02) : 157 - 161
  • [7] NORMAL VARIATIONS IN MULTIPLE PRECORDIAL LEADS
    MYERS, GB
    KLEIN, HA
    STOFER, BE
    HIRATZKA, T
    [J]. AMERICAN HEART JOURNAL, 1947, 34 (06) : 785 - 808
  • [8] EXPERIMENTAL HYPOTHERMIA - RESPIRATORY AND BLOOD PH CHANGES IN RELATION TO CARDIAC FUNCTION
    OSBORN, JJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1953, 175 (03): : 389 - 398
  • [9] Association of Early Repolarization Pattern on ECG with Risk of Cardiac and All-Cause Mortality: A Population-Based Prospective Cohort Study (MONICA/KORA)
    Sinner, Moritz F.
    Reinhard, Wibke
    Mueller, Martina
    Beckmann, Britt-Maria
    Martens, Eimo
    Perz, Siegfried
    Pfeufer, Arne
    Winogradow, Janina
    Stark, Klaus
    Meisinger, Christa
    Wichmann, H. -Erich
    Peters, Annette
    Riegger, Guenter A. J.
    Steinbeck, Gerhard
    Hengstenberg, Christian
    Kaab, Stefan
    [J]. PLOS MEDICINE, 2010, 7 (07)
  • [10] Long-Term Outcome Associated with Early Repolarization on Electrocardiography
    Tikkanen, Jani T.
    Anttonen, Olli
    Junttila, Juhani
    Aro, Aapo L.
    Kerola, Tuomas
    Rissanen, Harri A.
    Reunanen, Antti
    Huikuri, Heikki V.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (26) : 2529 - 2537