Prognostic value of ERCC1, RRM1, and TS proteins in patients with resected non-small cell lung cancer
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作者:
He, Yu-Wen
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Guangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
He, Yu-Wen
[1
]
Zhao, Mei-Ling
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Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
Zhao, Mei-Ling
[2
]
Yang, Xin-Yun
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Guangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
Yang, Xin-Yun
[1
]
Zeng, Jun
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Guangzhou Med Univ, Dept Med Genet & Cell Biol, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
Zeng, Jun
[3
]
Deng, Qiu-Hua
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Guangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
Deng, Qiu-Hua
[1
]
He, Jian-Xing
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Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510120, Guangdong, Peoples R ChinaGuangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
He, Jian-Xing
[2
]
机构:
[1] Guangzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
[2] Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510120, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Dept Med Genet & Cell Biol, Guangzhou 510120, Guangdong, Peoples R China
Recent clinical trials showed that expression of excision repair cross-complementation group 1 (ERCC1), ribonucleotide reductase M1 (RRM1), and thymidylate synthase (TS) proteins was able to predict the effects of non-small cell lung cancer (NSCLC) to chemotherapy. However, it remains unknown whether the adjuvant chemotherapy based on expression of the three proteins has survival significance in Chinese NSCLC patients. We investigated 128 Chinese patients receiving chemotherapy after tumor resection for expression of these proteins using immunohistochemistry. Based on protein expression, patients were assigned to two groups for different adjuvant chemotherapy regimes. The disease-free survival (DFS) data were collected and analyzed using Kaplan-Meier curves and Cox models. We found that DFS of these patients with carboplatin and a third-generation agent (gemcitabine or pemetrexed) stratified by protein expression showed no statistical difference between individual treatment versus non-individuation treatment analyzed using Kaplan-Meier method (P = 0.143, median 23.9 vs. 30.8 months). Furthermore, the multivariate analysis showed that histology and tumor stages were independent predictors for DFS in these patients. The results suggest that chemotherapy based on ERCC1, RRM1, and TS expression did not have significant impact on DFS of patients with resection of NSCLC.
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页码:861 / 867
页数:7
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[Anonymous], 2020, CA Cancer J Clin, DOI DOI 10.3322/CAAC.21590
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Karmanos Canc Inst, Detroit, MI 48201 USA
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Williams, Charles
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Williams, Charles
Schell, Michael J.
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Schell, Michael J.
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Karmanos Canc Inst, Detroit, MI 48201 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Karmanos Canc Inst, Detroit, MI 48201 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Johns Hopkins Med Ctr, Baltimore, MD USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Pinder-Schenck, Mary
Gray, Jhanelle
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Gray, Jhanelle
Haura, Eric
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Antonia, Scott
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Antonia, Scott
Fischer, Juergen R.
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Klinikum Loewenstein, Loewenstein, GermanyKarmanos Canc Inst, Detroit, MI 48201 USA
机构:
Karmanos Canc Inst, Detroit, MI 48201 USA
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Bepler, Gerold
Williams, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Williams, Charles
Schell, Michael J.
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h-index: 0
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Schell, Michael J.
Chen, Wei
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Karmanos Canc Inst, Detroit, MI 48201 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Chen, Wei
Zheng, Zhong
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机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Zheng, Zhong
Simon, George
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h-index: 0
机构:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Simon, George
Gadgeel, Shirish
论文数: 0引用数: 0
h-index: 0
机构:
Karmanos Canc Inst, Detroit, MI 48201 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Gadgeel, Shirish
Zhao, Xiuhua
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h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Zhao, Xiuhua
Schreiber, Fred
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h-index: 0
机构:
Watson Clin, Lakeland, FL USAKarmanos Canc Inst, Detroit, MI 48201 USA
Schreiber, Fred
Brahmer, Julie
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h-index: 0
机构:
Johns Hopkins Med Ctr, Baltimore, MD USAKarmanos Canc Inst, Detroit, MI 48201 USA
Brahmer, Julie
Chiappori, Alberto
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h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Chiappori, Alberto
Tanvetyanon, Tawee
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机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Tanvetyanon, Tawee
Pinder-Schenck, Mary
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Pinder-Schenck, Mary
Gray, Jhanelle
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机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Gray, Jhanelle
Haura, Eric
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Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
Haura, Eric
Antonia, Scott
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h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USAKarmanos Canc Inst, Detroit, MI 48201 USA
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Fischer, Juergen R.
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h-index: 0
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Klinikum Loewenstein, Loewenstein, GermanyKarmanos Canc Inst, Detroit, MI 48201 USA