Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes

被引：41

作者：

Kaplan, M ^{[1
]}

Hammerman, C

Vreman, HJ

Stevenson, DK

Beutler, E

机构：

[1] Shaare Zedek Med Ctr, Dept Neonatol, IL-91031 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

[3] Stanford Univ, Med Ctr, Div Pediat, Neonatal & Dev Metab Lab, Stanford, CA 94305 USA

[4] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA

来源：

JOURNAL OF PEDIATRICS | 2001年 / 139卷 / 01期

关键词：

D O I：

10.1067/mpd.2001.115312

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two premature female infants had severe hyperbilirubinemia caused by hemolysis. Both neonates were heterozygotes for the glucose-g-phosphate dehydrogenase Mediterranean mutation as determined by DNA analysis. Glucose-6-phosphate dehydrogenase-deficient heterozygotes may be susceptible to the complications of this enzyme deficiency.

引用

页码：137 / 140

页数：4

共 17 条

[1] G6PD DEFICIENCY [J].

BEUTLER, E .

BLOOD, 1994, 84 (11) :3613-3636

[2]

BEUTLER E, 1990, SEMIN HEMATOL, V27, P137

[3]

Doyle JJ, 1999, NEONATOLOGY PATHOPHY, P1045

[4]

FAIRBANKS VF, 1969, J AMER MED ASSOC, V208, P316

[5] Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes [J].

Kaplan, M ;

Beutler, E ;

Vreman, HJ ;

Hammerman, C ;

Levy-Lahad, E ;

Renbaum, P ;

Stevenson, DK .

PEDIATRICS, 1999, 104 (01) :68-74

[6] Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia [J].

Kaplan, M ;

Renbaum, P ;

LevyLahad, E ;

Hammerman, C ;

Lahad, A ;

Beutler, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :12128-12132

[7] Contribution of haemolysis to jaundice in Sephardic Jewish glucose-6-phosphate dehydrogenase deficient neonates [J].

Kaplan, M ;

Vreman, HJ ;

Hammerman, C ;

Leiter, C ;

Abramov, A ;

Stevenson, DK .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 (04) :822-827

[8] Severe neonatal hyperbilirubinemia - A potential complication of glucose-6-phosphate dehydrogenase deficiency [J].

Kaplan, M ;

Hammerman, C .

CLINICS IN PERINATOLOGY, 1998, 25 (03) :575-+

[9]

KATTAMIS C A, 1969, Journal of Medical Genetics, V6, P34, DOI 10.1136/jmg.6.1.34

[10] NEONATAL JAUNDICE AND SEVERITY OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY IN SARDINIAN BABIES [J].

MELONI, T ;

CUTILLO, S ;

TESTA, U ;

LUZZATTO, L .

EARLY HUMAN DEVELOPMENT, 1987, 15 (06) :317-322

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