Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs

被引:158
|
作者
Mou, Dongsheng [1 ]
Chen, Huabing [1 ]
Du, Danrong [1 ]
Mao, Chengwen [1 ]
Wan, Hangling [1 ]
Xu, Huibi [1 ]
Yang, Xiangliang [1 ]
机构
[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Inst Mat Med, Wuhan 430074, Peoples R China
关键词
nanoemulsion; topical delivery; camphor; menthol; methyl salicylate;
D O I
10.1016/j.ijpharm.2007.11.051
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this work, a hydrogel-thickened nanoemulsion system (HTN) with powerful permeation ability, good stability and suitable viscosity was investigated for topical delivery of active molecules. HTN was prepared to deliver an oily mixture of 5% camphor, 5% menthol and 5% methyl saticylate for topical therapy of arthritis, minor joint and muscle pain using soybean oil as the oil phase, soybean lecithin, Tween 80 and poloxamer 407 as the surfactants, propylene glycol as the cosurfactant, carbomer 940 as a thickening agent. The HTN system was found to combine the o/w microstructure of nanoemulsion with the gel network of hydrogel and had a suitable viscosity of 133.2 Pa S. The system had small average diameters and good long-term stability. The abilities of HTN to deliver the high amounts of camphor, menthol and methyl salicylate were evaluated using the in vitro permeation studies. The permeation rates of camphor, menthol and methyl salicylate from the optimal HTN formulation were 138.0 +/- 6.5, 63.6 +/- 3.3, 53.8 +/- 3.2 mu g cm(-2) h(-1) and showed the significant advantages over the control gel. The HTN with good stability and powerful permeation enhancing ability and suitable viscosity might be a promising prospective carrier for topical delivery of lipophilic drugs. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:270 / 276
页数:7
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