Rollinecins A and B: Two new bioactive annonaceous acetogenins from Rollinia mucosa

被引：11
作者：
Shi, G
Ye, Q
He, K
McLaughlin, JL
MacDougal, JM
机构：
[1] PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907
[2] MISSOURI BOT GARDEN,DIV HORT,ST LOUIS,MO 63166
来源：
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 05期
关键词：
D O I：
10.1021/np960128n
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new mono-THF ring acetogenins, rollinecins A (1) and B (2), were isolated from the partitioned ethanolic extracts of the leaves of Rollinia mucosa (Annonaceae) by activity-directed fractionation. 1 and 2 are epimeric at the C-14 carbinol stereocenter. Their absolute stereochemical structures were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed equivalent and selective in vitro activities against several human solid tumor cell lines.
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页码：548 / 551
页数：4
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