Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier

被引：36
|
作者：
Hosokawa, Takafumi [1 ]
Nakajima, Hideto [1 ,2 ]
Doi, Yoshimitsu [1 ]
Sugino, Masakazu [1 ]
Kimura, Fumiharu [1 ]
Hanafusa, Toshiaki [1 ]
Takahashi, Toshiyuki [3 ]
机构：
[1] Osaka Med Coll, Dept Internal Med 1, Osaka 5688686, Japan
[2] Seikeikai Hosp, Dept Internal Med, Osaka 5900024, Japan
[3] Tohoku Univ, Grad Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 236卷 / 1-2期
关键词：
Neuromyelitis optica; MMP-9; Blood-brain barrier; IL-8; Multiple sclerosis; Anti-aquaporin-4; antibody; MULTIPLE-SCLEROSIS; GELATINASE-B; ANTI-AQUAPORIN-4; ANTIBODY; MATRIX METALLOPROTEINASES; AQUAPORIN-4; DIAGNOSTIC-CRITERIA; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; IN-VIVO; BIOLOGY;
D O I：
10.1016/j.jneuroim.2011.04.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
相关论文
共 50 条
  • [41] Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis
    Felipe Dal-Pizzol
    Hugo Alberto Rojas
    Emilia Marcelina dos Santos
    Francieli Vuolo
    Larissa Constantino
    Gustavo Feier
    Matheus Pasquali
    Clarissa M. Comim
    Fabrícia Petronilho
    Daniel Pens Gelain
    João Quevedo
    José Cláudio Fonseca Moreira
    Cristiane Ritter
    Molecular Neurobiology, 2013, 48 : 62 - 70
  • [42] Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis
    Brilha, Sara
    Ong, Catherine W. M.
    Weksler, Babette
    Romero, Nacho
    Couraud, Pierre-Olivier
    Friedland, Jon S.
    SCIENTIFIC REPORTS, 2017, 7
  • [43] Matrix metalloproteinase-9 and p53 involved in chronic fluorosis induced blood-brain barrier damage and neurocyte changes
    Shen Qing-Feng
    Xia Ying-Peng
    Xu Tian-Tong
    ARCHIVES OF MEDICAL SCIENCE, 2019, 15 (02) : 457 - 466
  • [44] Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
    Lakhan, Shaheen E.
    Kirchgessner, Annette
    Tepper, Deborah
    Leonard, Aidan
    FRONTIERS IN NEUROLOGY, 2013, 4
  • [45] Apocynum venetum Leaf Extract Attenuates Disruption of the Blood-Brain Barrier and Upregulation of Matrix Metalloproteinase-9/-2 in a Rat Model of Cerebral Ischemia-Reperfusion Injury
    Xiang, Jun
    Lan, Rui
    Tang, Yu-Ping
    Chen, Yi-Ping
    Cai, Ding-Fang
    NEUROCHEMICAL RESEARCH, 2012, 37 (08) : 1820 - 1828
  • [46] Electroacupuncture ameliorates blood-brain barrier disruption after ischemic stroke through histone acetylation regulation at the matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 genes
    Chen, Yonglin
    Ling, Ouyang
    Meng, Lingling
    Wu, Bufan
    Peng, Rou
    Liu, Sitong
    Hou, Dan
    Wang, Yaling
    Jing, Xinyue
    Lu, Shengfeng
    Fu, Shuping
    JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2024, 44 (04) : 734 - 744
  • [47] Matrix Metalloproteinase-9 Mediates the Deleterious Effects of α2-Antiplasmin on Blood-Brain Barrier Breakdown and Ischemic Brain Injury in Experimental Stroke
    Singh, Satish
    Houng, Aiilyan K.
    Reed, Guy L.
    NEUROSCIENCE, 2018, 376 : 40 - 47
  • [48] A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion
    Miyamoto, Nobukazu
    Pham, Loc-Duyen D.
    Maki, Takakuni
    Liang, Anna C.
    Arai, Ken
    NEUROSCIENCE LETTERS, 2014, 573 : 40 - 45
  • [49] Amyloid-β-induced matrix metalloproteinase-9 secretion is associated with retinal pigment epithelial barrier disruption
    Cao, Lining
    Wang, Hao
    Wang, Fang
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 31 (05) : 1105 - 1112
  • [50] Coadministration of Branched-Chain Amino Acids and Lipopolysaccharide Causes Matrix Metalloproteinase Activation and Blood-Brain Barrier Breakdown
    Scaini, Giselli
    Morais, Meline O. S.
    Galant, Leticia S.
    Vuolo, Francieli
    Dall'Igna, Dhebora M.
    Pasquali, Matheus A. B.
    Ramos, Vitor M.
    Gelain, Daniel P.
    Moreira, Jose Claudio F.
    Schuck, Patricia F.
    Ferreira, Gustavo C.
    Soriano, Francisco G.
    Dal-Pizzol, Felipe
    Streck, Emilio L.
    MOLECULAR NEUROBIOLOGY, 2014, 50 (02) : 358 - 367
12345