Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier

被引：36
|
作者：
Hosokawa, Takafumi [1 ]
Nakajima, Hideto [1 ,2 ]
Doi, Yoshimitsu [1 ]
Sugino, Masakazu [1 ]
Kimura, Fumiharu [1 ]
Hanafusa, Toshiaki [1 ]
Takahashi, Toshiyuki [3 ]
机构：
[1] Osaka Med Coll, Dept Internal Med 1, Osaka 5688686, Japan
[2] Seikeikai Hosp, Dept Internal Med, Osaka 5900024, Japan
[3] Tohoku Univ, Grad Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 236卷 / 1-2期
关键词：
Neuromyelitis optica; MMP-9; Blood-brain barrier; IL-8; Multiple sclerosis; Anti-aquaporin-4; antibody; MULTIPLE-SCLEROSIS; GELATINASE-B; ANTI-AQUAPORIN-4; ANTIBODY; MATRIX METALLOPROTEINASES; AQUAPORIN-4; DIAGNOSTIC-CRITERIA; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; IN-VIVO; BIOLOGY;
D O I：
10.1016/j.jneuroim.2011.04.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
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