Increased serum matrix metalloproteinase-9 in neuromyelitis optica: Implication of disruption of blood-brain barrier

被引：38

作者：

Hosokawa, Takafumi ^{[1
]}

Nakajima, Hideto ^{[1
,2
]}

Doi, Yoshimitsu ^{[1
]}

Sugino, Masakazu ^{[1
]}

Kimura, Fumiharu ^{[1
]}

Hanafusa, Toshiaki ^{[1
]}

Takahashi, Toshiyuki ^{[3
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 1, Osaka 5688686, Japan

[2] Seikeikai Hosp, Dept Internal Med, Osaka 5900024, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 236卷 / 1-2期

关键词：

Neuromyelitis optica; MMP-9; Blood-brain barrier; IL-8; Multiple sclerosis; Anti-aquaporin-4; antibody; MULTIPLE-SCLEROSIS; GELATINASE-B; ANTI-AQUAPORIN-4; ANTIBODY; MATRIX METALLOPROTEINASES; AQUAPORIN-4; DIAGNOSTIC-CRITERIA; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; IN-VIVO; BIOLOGY;

D O I：

10.1016/j.jneuroim.2011.04.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：81 / 86

页数：6

共 40 条

[1] Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes [J].

Avolio, C ;

Ruggieri, M ;

Giuliani, F ;

Liuzzi, GM ;

Leante, R ;

Riccio, P ;

Livrea, P ;

Trojano, M .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 136 (1-2) :46-53

[2]

BAGGIOLINI M, 1994, ADV IMMUNOL, V55, P97

[3] Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis [J].

Benesova, Y. ;

Vasku, A. ;

Novotna, H. ;

Litzman, J. ;

Stourac, P. ;

Beranek, M. ;

Kadanka, Z. ;

Bednarik, J. .

MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (03) :316-322

[4] Neuromyelitis Optica: Pathogenicity of Patient Immunoglobulin In Vivo [J].

Bradl, Monika ;

Misu, Tatsuro ;

Takahashi, Toshiyuki ;

Watanabe, Mitsutoshi ;

Mader, Simone ;

Reindl, Markus ;

Adzemovic, Milena ;

Bauer, Jan ;

Berger, Thomas ;

Fujhara, Kazuo ;

Itoyama, Yasuto ;

Lassmann, Hans .

ANNALS OF NEUROLOGY, 2009, 66 (05) :630-643

[5] Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor [J].

Clements, JM ;

Cossins, JA ;

Wells, GMA ;

Corkill, DJ ;

Helfrich, K ;

Wood, LM ;

Pigott, R ;

Stabler, G ;

Ward, GA ;

Gearing, AJH ;

Miller, KM .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 74 (1-2) :85-94

[6]

Goetzl EJ, 1996, J IMMUNOL, V156, P1

[7] Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis [J].

Ishizu, T ;

Osoegawa, M ;

Mei, FJ ;

Kikuchi, H ;

Tanaka, M ;

Takakura, Y ;

Minohara, M ;

Murai, H ;

Mihara, F ;

Taniwaki, T ;

Kira, J .

BRAIN, 2005, 128 :988-1002

[8] Differential expression of matrix metalloproteinases in bacterial meningitis [J].

Kieseier, BC ;

Paul, R ;

Koedel, U ;

Seifert, T ;

Clements, JM ;

Gearing, AJH ;

Pfister, HW ;

Hartung, HP .

BRAIN, 1999, 122 :1579-1587

[9] Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum [J].

Kinoshita, Makoto ;

Nakatsuji, Yuji ;

Moriya, Masayuki ;

Okuno, Tatsusada ;

Kumanogoh, Atsushi ;

Nakano, Misa ;

Takahashi, Toshiyuki ;

Fujihara, Kazuo ;

Tanaka, Keiko ;

Sakoda, Saburo .

NEUROREPORT, 2009, 20 (05) :508-512

[10] Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid [J].

Kolb, SA ;

Lahrtz, F ;

Paul, R ;

Leppert, D ;

Nadal, D ;

Pfister, HW ;

Fontana, A .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 84 (02) :143-150

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