Endometriosis: A Disease with Few Direct Treatment Options

被引：56
作者：
Franca, Patricia Ribeiro de Carvalho [1 ]
Lontra, Anna Carolina Pereira [1 ]
Fernandes, Patricia Dias [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Lab Farmacol Dor & Inflamacao, BR-21941902 Rio De Janeiro, Brazil
来源：
MOLECULES | 2022年 / 27卷 / 13期
关键词：
endometriosis; gynecological disease; inflammation; drug therapy; DENDRITIC CELL-POPULATIONS; FACTOR-KAPPA-B; STROMAL CELLS; EUTOPIC ENDOMETRIUM; LYMPH-NODES; STEM-CELLS; PATHOGENESIS; EXPRESSION; DIAGNOSIS; CYTOKINES;
D O I：
10.3390/molecules27134034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.
引用
收藏
页数：20
相关论文
共 133 条
[101]   Aromatase inhibitors in the treatment of endometriosis [J].
Slopien, Radoslaw ;
Meczekalski, Blazej .
MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY, 2016, 15 (01) :43-47
[102]   Regulation of angiogenesis in the endometrium [J].
Smith, SK .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2001, 12 (04) :147-151
[103]   Impact of Endometriosis on Fatigue and Productivity Impairment in a Cross-Sectional Survey of Canadian Women [J].
Soliman, Ahmed M. ;
Rahal, Yasmine ;
Robert, Catherine ;
Defoy, Isabelle ;
Nisbet, Paul ;
Leyland, Nicholas ;
Singh, Sukhbir .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2021, 43 (01) :10-18
[104]   RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors [J].
Su, Fei ;
Viros, Amaya ;
Milagre, Carla ;
Trunzer, Kerstin ;
Bollag, Gideon ;
Spleiss, Olivia ;
Reis-Filho, Jorge S. ;
Kong, Xiangju ;
Koya, Richard C. ;
Flaherty, Keith T. ;
Chapman, Paul B. ;
Kim, Min Jung ;
Hayward, Robert ;
Martin, Matthew ;
Yang, Hong ;
Wang, Qiongqing ;
Hilton, Holly ;
Hang, Julie S. ;
Noe, Johannes ;
Lambros, Maryou ;
Geyer, Felipe ;
Dhomen, Nathalie ;
Niculescu-Duvaz, Ion ;
Zambon, Alfonso ;
Niculescu-Duvaz, Dan ;
Preece, Natasha ;
Robert, Lidia ;
Otte, Nicholas J. ;
Mok, Stephen ;
Kee, Damien ;
Ma, Yan ;
Zhang, Chao ;
Habets, Gaston ;
Burton, Elizabeth A. ;
Wong, Bernice ;
Hoa Nguyen ;
Kockx, Mark ;
Andries, Luc ;
Lestini, Brian ;
Nolop, Keith B. ;
Lee, Richard J. ;
Joe, Andrew K. ;
Troy, James L. ;
Gonzalez, Rene ;
Hutson, Thomas E. ;
Puzanov, Igor ;
Chmielowski, Bartosz ;
Springer, Caroline J. ;
McArthur, Grant A. ;
Sosman, Jeffrey A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (03) :207-215
[105]   Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium [J].
Suda, Kazuaki ;
Nakaoka, Hirofumi ;
Yoshihara, Kosuke ;
Ishiguro, Tatsuya ;
Adachi, Sosuke ;
Kase, Hiroaki ;
Motoyama, Teiichi ;
Inoue, Ituro ;
Enomoto, Takayuki .
HUMAN REPRODUCTION, 2019, 34 (10) :1899-1905
[106]   Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium [J].
Suda, Kazuaki ;
Nakaoka, Hirofumi ;
Yoshihara, Kosuke ;
Ishiguro, Tatsuya ;
Tamura, Ryo ;
Mori, Yutaro ;
Yamawaki, Kaoru ;
Adachi, Sosuke ;
Takahashi, Tomoko ;
Kase, Hiroaki ;
Tanaka, Kenichi ;
Yamamoto, Tadashi ;
Motoyama, Teiichi ;
Inoue, Ituro ;
Enomoto, Takayuki .
CELL REPORTS, 2018, 24 (07) :1777-1789
[107]   IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis [J].
Suen, Jau-Ling ;
Chang, Yu ;
Shiu, Yu-Shiang ;
Hsu, Chia-Yi ;
Sharma, Pooja ;
Chiu, Chien-Chih ;
Chen, Yi-Ju ;
Hour, Tzyh-Chyuan ;
Tsai, Eing-Mei .
JOURNAL OF PATHOLOGY, 2019, 249 (04) :485-497
[108]   Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model [J].
Symons, Lindsey K. ;
Miller, Jessica E. ;
Tyryshkin, Kathrin ;
Monsanto, Stephany P. ;
Marks, Ryan M. ;
Lingegowda, Harshavardhan ;
Vanderbeck, Kaitlin ;
Childs, Timothy ;
Young, Steven L. ;
Lessey, Bruce A. ;
Koti, Madhuri ;
Tayade, Chandrakant .
FASEB JOURNAL, 2020, 34 (01) :1558-1575
[109]   The Immunopathophysiology of Endometriosis [J].
Symons, Lindsey K. ;
Miller, Jessica E. ;
Kay, Vanessa R. ;
Marks, Ryan M. ;
Liblik, Kiera ;
Koti, Madhuri ;
Tayade, Chandrakant .
TRENDS IN MOLECULAR MEDICINE, 2018, 24 (09) :748-762
[110]   Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis [J].
Szukiewicz, Dariusz ;
Stangret, Aleksandra ;
Ruiz-Ruiz, Carmen ;
Olivares, Enrique G. ;
Soritau, Olga ;
Susman, Sergiu ;
Szewczyk, Grzegorz .
STEM CELL REVIEWS AND REPORTS, 2021, 17 (04) :1174-1193
567891011121314