Endometriosis: A Disease with Few Direct Treatment Options

被引：42
作者：
Franca, Patricia Ribeiro de Carvalho [1 ]
Lontra, Anna Carolina Pereira [1 ]
Fernandes, Patricia Dias [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Lab Farmacol Dor & Inflamacao, BR-21941902 Rio De Janeiro, Brazil
来源：
MOLECULES | 2022年 / 27卷 / 13期
关键词：
endometriosis; gynecological disease; inflammation; drug therapy; DENDRITIC CELL-POPULATIONS; FACTOR-KAPPA-B; STROMAL CELLS; EUTOPIC ENDOMETRIUM; LYMPH-NODES; STEM-CELLS; PATHOGENESIS; EXPRESSION; DIAGNOSIS; CYTOKINES;
D O I：
10.3390/molecules27134034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.
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页数：20
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共 133 条
  • [101] Aromatase inhibitors in the treatment of endometriosis
    Slopien, Radoslaw
    Meczekalski, Blazej
    [J]. MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY, 2016, 15 (01): : 43 - 47
  • [102] Regulation of angiogenesis in the endometrium
    Smith, SK
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2001, 12 (04) : 147 - 151
  • [103] Impact of Endometriosis on Fatigue and Productivity Impairment in a Cross-Sectional Survey of Canadian Women
    Soliman, Ahmed M.
    Rahal, Yasmine
    Robert, Catherine
    Defoy, Isabelle
    Nisbet, Paul
    Leyland, Nicholas
    Singh, Sukhbir
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2021, 43 (01) : 10 - 18
  • [104] RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
    Su, Fei
    Viros, Amaya
    Milagre, Carla
    Trunzer, Kerstin
    Bollag, Gideon
    Spleiss, Olivia
    Reis-Filho, Jorge S.
    Kong, Xiangju
    Koya, Richard C.
    Flaherty, Keith T.
    Chapman, Paul B.
    Kim, Min Jung
    Hayward, Robert
    Martin, Matthew
    Yang, Hong
    Wang, Qiongqing
    Hilton, Holly
    Hang, Julie S.
    Noe, Johannes
    Lambros, Maryou
    Geyer, Felipe
    Dhomen, Nathalie
    Niculescu-Duvaz, Ion
    Zambon, Alfonso
    Niculescu-Duvaz, Dan
    Preece, Natasha
    Robert, Lidia
    Otte, Nicholas J.
    Mok, Stephen
    Kee, Damien
    Ma, Yan
    Zhang, Chao
    Habets, Gaston
    Burton, Elizabeth A.
    Wong, Bernice
    Hoa Nguyen
    Kockx, Mark
    Andries, Luc
    Lestini, Brian
    Nolop, Keith B.
    Lee, Richard J.
    Joe, Andrew K.
    Troy, James L.
    Gonzalez, Rene
    Hutson, Thomas E.
    Puzanov, Igor
    Chmielowski, Bartosz
    Springer, Caroline J.
    McArthur, Grant A.
    Sosman, Jeffrey A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (03) : 207 - 215
  • [105] Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium
    Suda, Kazuaki
    Nakaoka, Hirofumi
    Yoshihara, Kosuke
    Ishiguro, Tatsuya
    Adachi, Sosuke
    Kase, Hiroaki
    Motoyama, Teiichi
    Inoue, Ituro
    Enomoto, Takayuki
    [J]. HUMAN REPRODUCTION, 2019, 34 (10) : 1899 - 1905
  • [106] Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
    Suda, Kazuaki
    Nakaoka, Hirofumi
    Yoshihara, Kosuke
    Ishiguro, Tatsuya
    Tamura, Ryo
    Mori, Yutaro
    Yamawaki, Kaoru
    Adachi, Sosuke
    Takahashi, Tomoko
    Kase, Hiroaki
    Tanaka, Kenichi
    Yamamoto, Tadashi
    Motoyama, Teiichi
    Inoue, Ituro
    Enomoto, Takayuki
    [J]. CELL REPORTS, 2018, 24 (07): : 1777 - 1789
  • [107] IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis
    Suen, Jau-Ling
    Chang, Yu
    Shiu, Yu-Shiang
    Hsu, Chia-Yi
    Sharma, Pooja
    Chiu, Chien-Chih
    Chen, Yi-Ju
    Hour, Tzyh-Chyuan
    Tsai, Eing-Mei
    [J]. JOURNAL OF PATHOLOGY, 2019, 249 (04) : 485 - 497
  • [108] Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model
    Symons, Lindsey K.
    Miller, Jessica E.
    Tyryshkin, Kathrin
    Monsanto, Stephany P.
    Marks, Ryan M.
    Lingegowda, Harshavardhan
    Vanderbeck, Kaitlin
    Childs, Timothy
    Young, Steven L.
    Lessey, Bruce A.
    Koti, Madhuri
    Tayade, Chandrakant
    [J]. FASEB JOURNAL, 2020, 34 (01) : 1558 - 1575
  • [109] The Immunopathophysiology of Endometriosis
    Symons, Lindsey K.
    Miller, Jessica E.
    Kay, Vanessa R.
    Marks, Ryan M.
    Liblik, Kiera
    Koti, Madhuri
    Tayade, Chandrakant
    [J]. TRENDS IN MOLECULAR MEDICINE, 2018, 24 (09) : 748 - 762
  • [110] Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis
    Szukiewicz, Dariusz
    Stangret, Aleksandra
    Ruiz-Ruiz, Carmen
    Olivares, Enrique G.
    Soritau, Olga
    Susman, Sergiu
    Szewczyk, Grzegorz
    [J]. STEM CELL REVIEWS AND REPORTS, 2021, 17 (04) : 1174 - 1193
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