Endometriosis: A Disease with Few Direct Treatment Options

被引：42
作者：
Franca, Patricia Ribeiro de Carvalho [1 ]
Lontra, Anna Carolina Pereira [1 ]
Fernandes, Patricia Dias [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Lab Farmacol Dor & Inflamacao, BR-21941902 Rio De Janeiro, Brazil
来源：
MOLECULES | 2022年 / 27卷 / 13期
关键词：
endometriosis; gynecological disease; inflammation; drug therapy; DENDRITIC CELL-POPULATIONS; FACTOR-KAPPA-B; STROMAL CELLS; EUTOPIC ENDOMETRIUM; LYMPH-NODES; STEM-CELLS; PATHOGENESIS; EXPRESSION; DIAGNOSIS; CYTOKINES;
D O I：
10.3390/molecules27134034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.
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页数：20
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共 133 条
  • [1] Endometriosis classification: an update
    Adamson, G. David
    [J]. CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2011, 23 (04) : 213 - 220
  • [2] Endometriosis fertility index: the new, validated endometriosis staging system
    Adamson, G. David
    Pasta, David J.
    [J]. FERTILITY AND STERILITY, 2010, 94 (05) : 1609 - 1615
  • [3] Pathophysiology and Immune Dysfunction in Endometriosis
    Ahn, Soo Hyun
    Monsanto, Stephany P.
    Miller, Caragh
    Singh, Sukhbir S.
    Thomas, Richard
    Tayade, Chandrakant
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [4] Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome
    Alkhuriji, Afrah F.
    Al Omar, Suliman Y.
    Babay, Zainb A.
    El-khadragy, Manal F.
    Mansour, Lamjed A.
    Alharbi, Wazirah G.
    Khalil, Mahmoud I.
    [J]. DISEASE MARKERS, 2020, 2020
  • [5] Endometriosis classification according to pain symptoms: can the ASRM classification be improved?
    Andres, Marina Paula
    Borrelli, Giuliano Moyses
    Abrao, Mauricio Simoes
    [J]. BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2018, 51 : 111 - 118
  • [6] Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells
    Arosh, Joe A.
    Lee, JeHoon
    Starzinski-Powitz, Anna
    Banu, Sakhila K.
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 409 (0C) : 51 - 58
  • [7] The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)
    Balkowiec, Magdalenia
    Maksym, Radoslaw B.
    Wlodarski, Pawel K.
    [J]. MOLECULAR MEDICINE REPORTS, 2018, 18 (03) : 3123 - 3136
  • [8] A Novel Pilot Study of Endometrial Stromal Cells and Immune Cell Populations in Sentinel Uterine-Draining Lymph Nodes During the Menstrual Cycle and in Endometriosis
    Berbic, Marina
    Ng, Cecilia H. M.
    Black, Kirsten
    Markham, Robert
    Russell, Peter
    Basten, Anthony
    Fraser, Ian S.
    Hey-Cunningham, Alison J.
    [J]. REPRODUCTIVE SCIENCES, 2013, 20 (11) : 1339 - 1348
  • [9] Endometriosis increases the risk of obstetrical and neonatal complications
    Berlac, Janne Foss
    Hartwell, Dorthe
    Skovlund, Charlotte Wessel
    Langhoff-Roos, Jens
    Lidegaard, Ojvind
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2017, 96 (06) : 751 - 760
  • [10] Endometriosis and adenomyosis are associated with increased risk of preterm delivery and a small-for-gestational-age child: a systematic review and meta-analysis
    Bruun, Mette R.
    Arendt, Linn H.
    Forman, Axel
    Ramlau-Hansen, Cecilia H.
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2018, 97 (09) : 1073 - 1090
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