cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

被引：40
作者：
Airoldi, Cristina [1 ]
Cardona, Francisco [1 ,2 ]
Sironi, Erika [1 ]
Colombo, Laura [3 ]
Salmona, Mario [3 ]
Silva, Artur [2 ]
Nicotra, Francesco [1 ]
La Ferla, Barbara [1 ]
机构：
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy
[2] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal
[3] Mario Negri Inst Pharmacol Res, Dept Mol Biochem & Pharmacol, I-20156 Milan, Italy
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 37期
关键词：
STD-NMR-SPECTROSCOPY; ALZHEIMERS-DISEASE; MOLECULAR-MECHANICS; BINDING; INHIBITORS;
D O I：
10.1039/c1cc13046c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with A beta peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.
引用
收藏
页码：10266 / 10268
页数：3
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