Isoxazolone based inhibitors of p38 MAP kinases

被引：36

作者：

Laufer, Stefan A. ^{[1
]}

Margutti, Simona ^{[1
]}

机构：

[1] Univ Tubingen, Dept Pharmaceut & Med Chem, Inst Pharm, D-72076 Tubingen, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 08期

关键词：

D O I：

10.1021/jm701343f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

引用

页码：2580 / 2584

页数：5

共 23 条

[1] Pyrimidinylimidazole inhibitors of CSBP/P37 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes
Adams, JL
Boehm, JC
Kassis, S
Gorycki, PD
Webb, EF
Hall, R
Sorenson, M
Lee, JC
Ayrton, A
Griswold, DE
Gallagher, TF
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (22) : 3111 - 3116
[2] BOEHM HJ, 1996, CHEM-EUR J, V2, P1509
[3] TAUTOMERISM OF HETEROAROMATIC COMPOUNDS WITH 5-MEMBERED RINGS .1. 5-HYDROXYISOXAZOLES-ISOXAZOL-5-ONES
BOULTON, AJ
KATRITZKY, AR
[J]. TETRAHEDRON, 1961, 12 (1-2) : 41 - &
[4] ISOTHIAZOLE CHEMISTRY .10. ACYLATION, ALKYLATION AND TAUTOMERISM IN 3-HYDROXYISOTHIAZOLE
CHAN, AWK
CROW, WD
GOSNEY, I
[J]. TETRAHEDRON, 1970, 26 (10) : 2497 - &
[5] CLARK M, 2002, Patent No. 15431
[6] CONCIONI R, 1968, TETRAHEDRON, V24, P151
[7] DANNHARDT G, 1989, SYNTHESIS-STUTTGART, V27, P5
[8] Elguero J, 1976, ADV HETEROCYCLIC S1, P656
[9] Franchini PF, 1968, CORSIE SEMIN CHIM, V14, P23
[10] Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists:: Synthesis, pharmacology, and molecular modeling
Frolund, B
Jensen, LS
Guandalini, L
Canillo, C
Vestergaard, HT
Kristiansen, U
Nielsen, B
Stensbol, TB
Madsen, C
Krogsgaard-Larszen, P
Liljefors, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (02) : 427 - 439

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