Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions

被引:162
作者
Gubbiotti, Maria A. [1 ,2 ]
Vallet, Sylvain D. [3 ]
Ricard-Blum, Sylvie [3 ]
Iozzo, Renato V. [1 ,2 ]
机构
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Canc Cell Biol & Signaling Program, Philadelphia, PA 19107 USA
[3] Univ Claude Bernard, Inst Mol & Supramol Chem & Biochem, Pericellular & Extracellular Supramol Assemblies, Lyon, France
基金
美国国家卫生研究院;
关键词
Decorin; Proteoglycan; Extracellular matrix; Tumorigenesis; Angiogenesis; Autophagy; Binding-partners; GROWTH-FACTOR-BETA; SMALL PROTEOGLYCAN DECORIN; STROMAL CORNEAL-DYSTROPHY; CHONDROITIN SULFATE PROTEOGLYCAN; LEUCINE-RICH PROTEOGLYCANS; LOW-DENSITY LIPOPROTEINS; NECROSIS-FACTOR-ALPHA; COLLAGEN TYPE-I; EXTRACELLULAR-MATRIX; FACTOR RECEPTOR;
D O I
10.1016/j.matbio.2016.09.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/protein interactions also including interactions with its single glycosaminoglycan side chain. The decorin-binding partners encompass numerous categories ranging from extracellular matrix molecules to cell surface receptors to growth factors and enzymes. Despite the diversity of the decorin interacting network, two main roles emerge as prominent themes in decorin function: maintenance of cellular structure and outside-in signaling, culminating in anti-tumorigenic effects. Here we present contemporary knowledge regarding the decorin interacting network and discuss in detail the biological relevance of these pleiotropic interactions, some of which could be targeted by therapeutic interventions. (C) 2016 Published by Elsevier B.V.
引用
收藏
页码:7 / 21
页数:15
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