Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

被引：478

作者：

Antimisiaris, Sophia G. ^{[1
,2
]}

Mourtas, Spyridon ^{[2
]}

Marazioti, Antonia ^{[2
]}

机构：

[1] Univ Patras, Dept Pharm, Lab Pharmaceut Technol, Rion 26504, Greece

[2] Fdn Res & Technol Hellas, FORTH ICE HT, Inst Chem Engn, Rion 26504, Greece

来源：

PHARMACEUTICS | 2018年 / 10卷 / 04期

关键词：

liposomes; exosomes; extracellular vesicles; drug delivery; drug targeting; bioinspired systems; engineered systems; MESENCHYMAL STROMAL CELLS; BLOOD-BRAIN-BARRIER; EXTRACELLULAR VESICLES; MEMBRANE-VESICLES; B16BL6-DERIVED EXOSOMES; MIMETIC NANOVESICLES; MEDIATED DELIVERY; MESSENGER-RNA; EMERGING ROLE; STEM-CELLS;

D O I：

10.3390/pharmaceutics10040218

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.

引用

页数：40

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