The effect of time to sentinel lymph node biopsy on cutaneous melanoma survival

被引：15

作者：

Fortes, Cristina ^{[1
]}

Mastroeni, Simona ^{[1
]}

Caggiati, Alessio ^{[2
]}

Passarelli, Francesca ^{[3
]}

Zappala, Alba ^{[4
]}

Capuano, Maria ^{[5
]}

Bono, Riccardo ^{[6
]}

Nudo, Maurizio ^{[6
]}

Marino, Claudia ^{[7
]}

Michelozzi, Paola ^{[7
]}

机构：

[1] IDI IRCCS FLMM, Epidemiol Unit, Via Monti di Creta 104, I-00167 Rome, Italy

[2] IDI IRCCS FLMM, Plast Surg Unit, Rome, Italy

[3] IDI IRCCS FLMM, Pathol Unit, Rome, Italy

[4] IDI IRCCS FLMM, Oncol Unit, Rome, Italy

[5] IDI IRCCS FLMM, Div Dermatol, Viterbo, Italy

[6] IDI IRCCS FLMM, Div Dermatol 5, Rome, Italy

[7] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

来源：

AMERICAN JOURNAL OF SURGERY | 2016年 / 212卷 / 05期

关键词：

Melanoma; Sentinel lymph node; Mortality; Timing; PROGNOSTIC-FACTORS; TECHNICAL DETAILS; THICKNESS; DISSECTION;

D O I：

10.1016/j.amjsurg.2016.02.025

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality. METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models. RESULTS: After adjusting for sex, age, Breslow thickness, mitotic rate, ulceration, and histologic type, patients who underwent early SLNB (<= 30 days) and resulted positive on final pathology had a 3 times decreased risk of melanoma mortality (hazard ratio = .29; 95% confidence interval = .11 to .77) in comparison to patients who underwent delayed SLNB (>= 31 days) and resulted positive on final pathology. CONCLUSIONS: Our findings suggest that early SLNB (<= 30 days) improves melanoma survival. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：935 / 940

页数：6

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