Protective effects of selenium on malathion-induced testicular toxicity in mice

被引：0
|
作者：
Ibrahim, Mahrous A. [1 ,2 ]
Wani, Farooq A. [3 ]
Khalifa, Athar M. [3 ]
Kelleni, Mina T. [4 ,5 ]
Anwar, Marwa M. [2 ]
Thirunavukkarasu, Ashokkumar [6 ]
Sayeed, Mohammed U. [3 ]
机构：
[1] Jouf Univ, Coll Med, Forens Med & Clin Toxicol, Sakaka, Saudi Arabia
[2] Suez Canal Univ, Fac Med, Forens Med & Clin Toxicol Dept, Ismailia, Egypt
[3] Jouf Univ, Coll Med, Pathol Dept, Sakaka, Saudi Arabia
[4] Menia Univ, Fac Med, Pharmacol Dept, Al Minya, Egypt
[5] Jouf Univ, Pharmacol Dept, Coll Pharm, Sakaka, Saudi Arabia
[6] Jouf Univ, Community Med Dept, Coll Med, Sakaka, Saudi Arabia
来源：
INDIAN JOURNAL OF ANIMAL RESEARCH | 2020年 / 54卷 / 03期
关键词：
Organophosphate pesticides; Oxidative stress; Selenium; Testicular toxicity; INDUCED OXIDATIVE STRESS; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; VITAMINS C; DNA-DAMAGE; KIDNEY; LIVER;
D O I：
10.18805/ijar.B-1083
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The aim of this study was to investigate the possible protective effect of the antioxidant sodium selenite (0.1 mg/kg/day) via gavage once a day for 30 days for the first time in a model of malathion (27 mg/kg/day) via gavage once a day for 30 days induced testicular toxicity in mice. Results of this study revealed that concomitant administration of selenium has prevented the decrease in mean final and relative body weight as well as testicular and relative testicular weight as compared to malathion group. Concomitant selenium administration has also decreased malondialdehyde contents and increased serum levels of follicle stimulating hormone, luteinizing hormone, testosterone, acetylcholinesterase and testicular levels and activities of glutathione, glutathione peroxidase, catalase, superoxide dismutase and improved the testicular histopathological features as compared to malathion group.
引用
收藏
页码：335 / 341
页数：7
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