Given a graph G=(V,E) and a weight function on the edges w:E -> a"e, we consider the polyhedron P(G,w) of negative-weight flows on G, and get a complete characterization of the vertices and extreme directions of P(G,w). Based on this characterization, and using a construction developed in Khachiyan et al. (Discrete Comput. Geom. 39(1-3):174-190, 2008), we show that, unless P=NP, there is no output polynomial-time algorithm to generate all the vertices of a 0/1-polyhedron. This strengthens the NP-hardness result of Khachiyan et al. (Discrete Comput. Geom. 39(1-3):174-190, 2008) for non 0/1-polyhedra, and comes in contrast with the polynomiality of vertex enumeration for 0/1-polytopes (Bussiech and Lubbecke in Comput. Geom., Theory Appl. 11(2):103-109, 1998). As further applications, we show that it is NP-hard to check if a given integral polyhedron is 0/1, or if a given polyhedron is half-integral. Finally, we also show that it is NP-hard to approximate the maximum support of a vertex of a polyhedron in a"e (n) within a factor of 12/n.