Cardiovascular disease (CVD) and type 2 diabetes (T2D) are leading causes of morbidity and mortality among US Latinas. Family history is increasingly used to determine risk for these chronic, multifactorial diseases and to direct prevention interventions. This article provides a brief review on family history screening for CVD and T2D risk identification and presents the results of a pilot study to translate and evaluate the use of a family history tool for Spanish-speaking Latinas. Implications for the use of family history screening to guide CVD and T2D prevention interventions with Latinas are discussed.