Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

被引：4157
|
作者：
Filipowicz, Witold [1 ]
Bhattacharyya, Suvendra N. [1 ]
Sonenberg, Nahum [2 ,3 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
来源：
NATURE REVIEWS GENETICS | 2008年 / 9卷 / 02期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nrg2290
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In mammals, microRNAs are predicted to control the activity of approximately 30% of all protein-coding genes, and have been shown to participate in the regulation of almost every cellular process investigated so far. By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation. This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function.
引用
收藏
页码：102 / 114
页数：13
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