Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

被引：4157
|
作者：
Filipowicz, Witold [1 ]
Bhattacharyya, Suvendra N. [1 ]
Sonenberg, Nahum [2 ,3 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
来源：
NATURE REVIEWS GENETICS | 2008年 / 9卷 / 02期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nrg2290
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In mammals, microRNAs are predicted to control the activity of approximately 30% of all protein-coding genes, and have been shown to participate in the regulation of almost every cellular process investigated so far. By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation. This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function.
引用
收藏
页码：102 / 114
页数：13
相关论文
共 50 条
  • [1] Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    Witold Filipowicz
    Suvendra N. Bhattacharyya
    Nahum Sonenberg
    Nature Reviews Genetics, 2008, 9 : 102 - 114
  • [2] Post-transcriptional regulation of polycistronic microRNAs
    Vilimova, Monika
    Pfeffer, Sebastien
    WILEY INTERDISCIPLINARY REVIEWS-RNA, 2023, 14 (02)
  • [3] MicroRNAs and post-transcriptional regulation of skeletal development
    Gamez, Beatriz
    Rodriguez-Carballo, Edgardo
    Ventura, Francesc
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2014, 52 (03) : R179 - R197
  • [4] Computational modeling of post-transcriptional gene regulation by microRNAs
    Khanin, Raya
    Vinciotti, Veronica
    JOURNAL OF COMPUTATIONAL BIOLOGY, 2008, 15 (03) : 305 - 316
  • [5] Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis
    Chang, Sung-Hee
    Hla, Timothy
    CURRENT OPINION IN HEMATOLOGY, 2014, 21 (03) : 235 - 240
  • [6] Evidence for post-transcriptional regulation of clustered microRNAs in Drosophila
    Ryazansky, Sergei S.
    Gvozdev, Vladimir A.
    Berezikov, Eugene
    BMC GENOMICS, 2011, 12
  • [7] Evidence for post-transcriptional regulation of clustered microRNAs in Drosophila
    Sergei S Ryazansky
    Vladimir A Gvozdev
    Eugene Berezikov
    BMC Genomics, 12
  • [8] The next level of complexity: post-transcriptional regulation by microRNAs
    Kramann, Rafael
    Moeller, Marcus J.
    KIDNEY INTERNATIONAL, 2011, 80 (07) : 692 - 693
  • [9] Regulation of invertase: a suite of transcriptional and post-transcriptional mechanisms
    Huang, Li-Fen
    Bocock, Philip N.
    Davis, John M.
    Koch, Karen E.
    FUNCTIONAL PLANT BIOLOGY, 2007, 34 (06) : 499 - 507
  • [10] Origins of binary gene expression in post-transcriptional regulation by microRNAs
    Bose, I.
    Ghosh, S.
    EUROPEAN PHYSICAL JOURNAL E, 2012, 35 (10):
12345