Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

被引：4161
作者：
Filipowicz, Witold [1 ]
Bhattacharyya, Suvendra N. [1 ]
Sonenberg, Nahum [2 ,3 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
来源：
NATURE REVIEWS GENETICS | 2008年 / 9卷 / 02期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nrg2290
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In mammals, microRNAs are predicted to control the activity of approximately 30% of all protein-coding genes, and have been shown to participate in the regulation of almost every cellular process investigated so far. By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation. This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function.
引用
收藏
页码：102 / 114
页数：13
相关论文
共 138 条
  • [1] Comparison of siRNA-induced off-target RNA and protein effects
    Aleman, Lourdes M.
    Doench, John
    Sharp, Phillip A.
    [J]. RNA, 2007, 13 (03) : 385 - 395
  • [2] RNA granules
    Anderson, P
    Kedersha, N
    [J]. JOURNAL OF CELL BIOLOGY, 2006, 172 (06) : 803 - 808
  • [3] A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies
    Andrei, MA
    Ingelfinger, D
    Heintzmann, R
    Achsel, T
    Rivera-Pomar, R
    Lührmann, R
    [J]. RNA, 2005, 11 (05) : 717 - 727
  • [4] [Anonymous], 2007, SCI SINGAL, DOI DOI 10.1126/STKE.3672007RE1
  • [5] Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
    Ashraf, SI
    McLoon, AL
    Sclarsic, SM
    Kunes, S
    [J]. CELL, 2006, 124 (01) : 191 - 205
  • [6] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    Bagga, S
    Bracht, J
    Hunter, S
    Massirer, K
    Holtz, J
    Eachus, R
    Pasquinelli, AE
    [J]. CELL, 2005, 122 (04) : 553 - 563
  • [7] MicroRNA binding sites in Arabidopsis class IIIHD-ZIP mRNAs are required for methylation of the template chromosome
    Bao, N
    Lye, KW
    Barton, MK
    [J]. DEVELOPMENTAL CELL, 2004, 7 (05) : 653 - 662
  • [8] Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies
    Barbee, Scott A.
    Estes, Patricia S.
    Cziko, Anne-Marie
    Hillebrand, Jens
    Luedeman, Rene A.
    Coller, Jeff M.
    Johnson, Nick
    Howlett, Iris C.
    Geng, Cuiyun
    Ueda, Ryu
    Brand, Andrea H.
    Newbury, Sarah F.
    Wilhelm, James E.
    Levine, Richard B.
    Nakamura, Akira
    Parker, Roy
    Ramaswami, Mani
    [J]. NEURON, 2006, 52 (06) : 997 - 1009
  • [9] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [10] The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis
    Basu, U
    Si, K
    Warner, JR
    Maitra, U
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) : 1453 - 1462
12345678910