CTP synthase forms the cytoophidium in human hepatocellular carcinoma

被引：52
作者：
Chang, Chia-Chun [1 ,2 ]
Jeng, Yung-Ming [3 ,4 ]
Peng, Min [2 ]
Keppeke, Gerson Dierley [1 ]
Sung, Li-Ying [2 ,5 ]
Liu, Ji-Long [1 ,6 ]
机构：
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
[2] Natl Taiwan Univ, Inst Biotechnol, Taipei 106, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Pathol, Taipei 10002, Taiwan
[4] Natl Taiwan Univ, Grad Inst Pathol, Coll Med, Taipei 10051, Taiwan
[5] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan
[6] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2017年 / 361卷 / 02期
基金：
英国医学研究理事会;
关键词：
CTP synthase; Cytoophidium; Glutamine metabolism; Heatshock protein 90; Human hepatocellular carcinoma; Nucleotide; Protein filamentation; Pyrimidine; SYNTHETASE-ACTIVITY; HSP90; COMPARTMENTATION; EXPRESSION; PROTEINS; REVEALS; COMPLEX;
D O I：
10.1016/j.yexcr.2017.10.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma.
引用
收藏
页码：292 / 299
页数：8
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