Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection

被引：62

作者：

Zhang, Wenting ^{[1
,2
]}

Li, Peiying ^{[1
,2
,3
,4
]}

Hu, Xiaoming ^{[3
,4
]}

Zhang, Feng ^{[3
,4
]}

Chen, Jun ^{[1
,2
,3
,4
]}

Gao, Yanqin ^{[1
,2
]}

机构：

[1] Huanshan Hosp, Dept Anesthesiol, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Brain Sci, Shanghai 200032, Peoples R China

[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, Ctr Cerebrovasc Dis Res, Pittsburgh, PA 15213 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

关键词：

DHA; ischemia; Alzheimer's disease; Parkinson's disease; Review; GLYCOGEN-SYNTHASE KINASE-3-BETA; ALZHEIMERS-DISEASE MODEL; GROWTH-FACTOR EXPRESSION; FOCAL CEREBRAL-ISCHEMIA; ALPHA-LINOLENIC ACID; INSULIN-RECEPTOR SUBSTRATE; RAT HIPPOCAMPAL-NEURONS; AMYLOID-BETA-PEPTIDE; N-TERMINAL KINASE; DOCOSAHEXAENOIC ACID;

D O I：

10.2741/3878

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a group of essential fatty acids that serve as energy substrates and integral membrane components, and therefore play crucial roles in the maintenance of normal neurological function. Recent studies show that n-3 PUFAs display neuroprotective properties and exert beneficial effects on the cognitive function with aging. The brain's need of n-3 PUFAs is predominantly met by the blood delivery due to their limited synthesis in the brain. The present review focuses on the metabolism of n-3 PUFAs in the brain, including their accumulation and turnover. We also highlight the current understanding of the neuroprotective effects of n-3 PUFAs against cerebral ischemia and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

引用

页码：2653 / 2670

页数：18

共 172 条

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